Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population

Spetz, Anna-Clara; Palmefors, Lennart; Skobe, R Staffan P; Strömstedt, Martin T; Fredriksson, Mats; Theodorsson, Elvar; Hammar, Mats

doi:10.1097/gme.0b013e318057786b

Cited by 26 publications

(41 citation statements)

References 23 publications

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“…The questionnaire was modified from previously used and validated questionnaires developed by us (29)(30)(31). To test comprehension, six women, 47-56 years old, were asked to answer the questionnaire in writing.…”

Section: Cross-sectional Study Performed In 2010mentioning

confidence: 99%

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

et al. 2014

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Objectives The use of hormone therapy (HT) for hot flushes has changed dramatically over the past five decades.In this cross-sectional questionnaire study, the aim was to describe the use of HT and alternative treatments and to study the frequency of hot flushes. A further aim was to compare data from the present questionnaire with data from previous studies made in the same geographic area.Method A questionnaire was sent to a random sample of 2,000 women aged 47-56 years living in Östergötland County, Sweden. The results were compared with findings from previous studies regarding use of HT, alternative treatment and hot flushes, and the number of HT prescriptions dispensed during the corresponding time using data derived from the Swedish Prescribed Drug Registry. ResultsThe response rate was 66%. Six percent used HT, in line with prevalence data from the Swedish Prescribed Drug Registry. Alternative treatments were used by 10%. About 70% of postmenopausal women reported flushes and almost one third of those with flushes stated that they would be positive to HT if therapy could be shown to be harmless, a view more often stated by women with severe complaints of hot flushes (67%). ConclusionThe use of HT and alternative treatments is low and many women suffer from flushes that could be treated. Women considered their knowledge of the climacteric period and treatment options as insufficient. Individualized information should be given and women with significant climacteric complaints, without contraindications, should be given the opportunity to try HT.3

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Section: Cross-sectional Study Performed In 2010mentioning

confidence: 99%

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

et al. 2014

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“…In a cross-sectional study of men in Sweden, performed in 2003, we investigated the prevalence of probable symptoms of LOH and associated them with testosterone concentrations [12]. We found that symptoms associated with LOH often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes why we suggest that hot flushes should be addressed as a possible LOH-symptom.…”

Section: Partial Androgen Deficiency In Aging Males (Padam) or Androgmentioning

confidence: 82%

“…Since we have previously investigated possible symptoms of LOH and measured T and BT in men 55 to 75 years old [12,13], and since the decline in androgens seems to begin earlier than previously believed, i.e. at approximately age 30 [3], we wanted to investigate symptoms of testosterone deficiency and androgen concentrations in a an even younger group of men.…”

Section: Partial Androgen Deficiency In Aging Males (Padam) or Androgmentioning

confidence: 99%

“…Therefore we made a score; "ADAM-positivity and -negativity", respectively, meaning that men positive for the ADAM-questionnaire (answering "yes" to item 1 or 7 or "yes" to any other three questions or more) were "ADAM-positive", and all other men were "ADAMnegative" [12]. We also developed a term called "ADAM-sum", according to the number of "yes" replies in the questionnaire.…”

Section: The Adam-questionnairementioning

confidence: 99%

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Symptoms of testosterone deficiency in early middle aged men

Holm¹,

Fredrikson²,

Hammar³

2012

The Aging Male

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Symptoms of testosterone deficiency and concentrations of testosterone (T) and bioavailable testosterone (BT) were studied in 35-and 45-year-old men. Methods: A questionnaire, was sent to all 35-and 45-year-old men in Linkoping, Sweden (n = 1998). The questionnaire has earlier been used for 55- to 75-year-old men and included demographic data, medical history, different symptoms possibly of T deficiency and the 10 questions from the "ADAM-questionnaire". Totally 200 men randomly selected among the men who answered the questionnaire were asked to give blood samples for analysis of T-and BT-concentrations. Results: A total of 38.7% of the questionnaires were returned and analysed, and 43.5% of the 200 randomly selected men gave blood samples. The older age group reported more symptoms that may be connected to low B and BT and had lower T-and BT-concentrations. Less strong erections and higher alcohol consumption were associated with lower concentrations of BT in 45-year-old men. Conclusions: The burden of symptoms possibly related to low T concentrations were higher in 45-year-old men, and BT and T were lower. However, due to the low answer frequency and number of blood samples analyzed no general conclusions can be drawn

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“…56 In comparison with clinically well-defined menopause, andropause symptoms would be rather subtle and seem to affect sexual functions, bone and muscle mass, body composition, and cardiovascular health and results in mood and cognitive disorders. 55 However, it is important to state that some men have a lower than normal T level without signs or symptoms.…”

Section: Lang Et Al Clinical Meaningfulness Of T Decline In Older Menmentioning

confidence: 99%

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Lang

Samaras

2012

Rejuvenation Research

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Testosterone replacement therapy is often equated with the macho male physique and virility and is viewed by some as an antiaging tonic. The growth in testosterone's reputation and its increased use by men of all ages has seemed to outpace the scientific evidences. This review will aim to examine the uncertainty regarding the nature and the clinical importance of the age-related reduction in the testosterone levels. Considerations will be given both to clinical symptoms, biochemical and clinical diagnostic criteria, and to the risk-to-benefit ratio of reversing late-onset hypogonadism in aging and older men.

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Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population

Abstract: Symptoms associated with PADAM often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes. It is likely that these symptoms have a more complex background than only PADAM.

Cited by 26 publications

References 23 publications

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

Symptoms of testosterone deficiency in early middle aged men

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

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