Background: Fibrinogen concentrations and the monocyte-to-lymphocyte ratio (FC-MLR) are associated with progression and outcomes of many malignancies. This study aimed to assess the clinical and prognostic significance of the combination of plasma FC-MLR in patients with ovarian cancer. Methods: A total of 155 patients with epithelial ovarian cancer (EOC) and 102 patients with benign gynecological disease were retrospectively reviewed. The clinical and pathological data of all patients with EOC were analyzed. Plasma fibrinogen concentrations and the white blood cell (WBC) count were measured to calculate the MLR and neutrophil-to-lymphocyte ratio (NLR). Furthermore, the association of fibrinogen concentrations, the MLR, and FC-MLR with tumor stage, lymphatic and venous metastasis, and 5-year survival was assessed. Regression analysis was performed to evaluate the risk factors for progression of EOC. Receiver operating characteristic (ROC) curves were constructed to assess the prognostic power of plasma fibrinogen concentrations, the MLR, and FC-MLR, and to determine the optimal cutoff values of fibrinogen and the MLR. On the basis of the cutoff values, patients with EOC were divided into three groups: no abnormality, either increased, and both increased groups, respectively. The effect of FC-MLR on overall survival was calculated by the Kaplan-Meier method and compared by the log-rank test in the three groups. Results: Patients with EOC had higher fibrinogen concentrations and a higher MLR than did controls (both P<0.01), and FC-MLR was closely associated with tumor stage and lymphatic and venous metastasis (all P<0.001). Furthermore, FC-MLR was an independent risk factor for progression of EOC (OR =8.985; 95% CI: 4.912-27.166; P<0.001), and patients with high fibrinogen concentrations and a high MLR showed a lower 5-year survival rate (P<0.001). Conclusions: FC-MLR may be used as a predictor of tumor progression and prognosis for ovarian cancer.
The
sensing of temperature is closely related to human life. The
noncontact ratio temperature measurement method has extensive applications
in biochemical monitoring and industrial production. However, optical
detection techniques based on fluorescence intensity ratio (FIR) still
face many challenges, such as laser thermal effects, accuracy, and
reversibility. In this article, the Yb3+/Er3+-codoped Bi4Ti3O12 nanocrystalline
composite has been developed for thermometer. The introduction of
Bi4Ti3O12 nanocrystals into the glass
matrix exceptionally enhances the upconversion emission of Er3+ ions. The Yb3+/Er3+-codoped Bi4Ti3O12 nanocrystalline composite enables
online temperature measurement under low power excitation density
(0.75 W/cm2), which can reduce the thermal effect of the
laser. In addition, Yb3+/Er3+-codoped nanocrystalline
composite has excellent precision of temperature measurement in the
temperature range of 293–573 K. The value of absolute sensitivity S
a is 5.2 × 10–3. The
maximum value of the relative error between the measured temperature
and the actual temperature does not exceed 0.4% in the reliability
test, and temperature measurement has excellent repeatability. Therefore,
the developed Yb3+/Er3+-codoped nanocrystalline
composite is a promising candidate for ratiometric thermometry.
Metal-based fuel borne catalysts (FBC) have been extensively studied as an effective technology to reduce diesel particles and assist diesel particulate filter (DPF) regeneration. In this study, FBC fuels were prepared with Fe element mass fractions of 0, 100, 200, 300 and 400 mg/kg (marked as Diesel, Fe100, Fe200, Fe300 and Fe400). The effects of FBC additions on fuel economy and emission characteristics were carried out on a common-rail engine. Also, particle size distribution, microstructure, surface functional groups, element content and oxidation properties of exhaust particles were systematically analyzed. Results showed that the brake thermal efficiency was improved with the addition of FBC in diesel fuel, especially at low load, and the NOx and smoke emissions showed a decreasing trend. Compared with Diesel particles, the total mass concentration and the mean particle diameter of Fe300 particles decreased, the overall particle size distribution moved from coarse mode to accumulation mode, however, the total number concentration increased. Fe300 particles had larger layer spacing and microcrystalline curvature, smaller microcrystalline size and lower graphitization. In addition, the relative contents of OH and aliphatic C-H in Fe300 particles were higher than those in Diesel particles. The relative content of C atoms in Fe300 particles decreased, while the relative content of O atoms increased. Temperature-programmed-oxidation experiments indicated that semi-volatile organic components appeared in Fe300 particles, the peak temperature of weight loss rate decreased by 131 °C as compared with Diesel particles, the activation energy was also significantly lower, and therefore the particle oxidation activity was improved.
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