Nowadays, green synthesis methods have gained growing attention in nanotechnology owning to their versatile features including high efficiency, cost-effectiveness, and eco-friendliness. Here, the aqueous extract of Chlorophytum comosum leaf was applied for the preparation of iron nanoparticles (INPs) to obtain spherical and amorphous INPs with a particle size below 100 nm as confirmed by TEM. The synthesized INPs managed to eliminate methyl orange (MO) from the aqueous solution. The concentration of MO can be easily checked via ultraviolet-visible (UV-Vis) spectroscopy throughout the usage of INPs at the presence of H 2 O 2 . The synthesized INPs exhibited MO degradation efficiency of 77% after 6 h. Furthermore, the synthesized INPs exhibited antibacterial activity against both Gram-negative and Gram-positive bacteria. The prepared INPs have an impressive effect on Staphylococcus aureus at concentrations below 6 μg/ml. Overall, the synthesized INPs could considerably contribute to our combat against organic dyes and bacteria.
Multi-component reactions (MCRs) have proved to be remarkably successful in generating products in a single synthetic operation. 1 The success of these reactions provided an impetus for generating a variety of novel, drug-like scaffolds in combinatorial chemistry, owing to their high productivity, facile execution, atom economy, convergent character, and the simplicity of a one-pot procedure. Recently, isocyanide-based multicomponent reactions (IMCR) have assumed a position of importance in synthetic organic chemistry. 2 One class of IMCRs involving the generation and interception of the zwitterionic nucleophilic addition product of isocyanides to activated acetylenes has been known for a long time. 3 Such a reaction of an isocyanides with dimethyl acetylenedicarboxylate (DMAD) has been applied to the synthesis of various types of heterocyclic compounds. [4][5][6] 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) and their derivatives are an important class of heterocyclic compounds which possess various types of biological and pharmacological properties such as antiviral, anticarcinogenic, and antihypertensive activity and, most importantly, are effective as calcium channel modulators. [7][8][9][10][11] Continuing our interest in isocyanide-based MCRs with electron deficient acetylenic esters, 12 we now report a novel three-component reaction for the synthesis of dialkyl 2-(alkylamino)-5-(4-nitrophenyl)-7,9, 1-trioxo-1-oxa-5,8,10-triazaspiro[5.5]undec-2-ene-3,4-dicarboxylate derivatives.
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