In recent years, machine learning techniques have received increasing attention as a promising approach to differentiating patients from healthy subjects. Therefore, some resting-state functional magnetic resonance neuroimaging (R-fMRI) studies have used interregional functional connections as discriminative features. The aim of this study was to investigate ADHD-related spatially distributed discriminative features derived from wholebrain resting-state functional connectivity patterns using machine learning. Patients and Methods: We measured the interregional functional connections of the R-fMRI data from 40 ADHD patients and 28 matched typically developing controls. Machine learning was used to discriminate ADHD patients from controls. Classification performance was assessed by permutation tests. Results: The results from the model with the highest classification accuracy showed that 85.3% of participants were correctly identified using leave-one-out cross-validation (LOOV) with support vector machine (SVM). The majority of the most discriminative functional connections were located within or between the cerebellum, default mode network (DMN) and frontoparietal regions. Approximately half of the most discriminative connections were associated with the cerebellum. The cerebellum, right superior orbitofrontal cortex, left olfactory cortex, left gyrus rectus, right superior temporal pole, right calcarine gyrus and bilateral inferior occipital cortex showed the highest discriminative power in classification. Regarding the brain-behaviour relationships, some functional connections between the cerebellum and DMN regions were significantly correlated with behavioural symptoms in ADHD (P < 0.05). Conclusion: This study indicated that whole-brain resting-state functional connections might provide potential neuroimaging-based information for clinically assisting the diagnosis of ADHD.

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An increasing number of resting-state functional magnetic resonance neuroimaging (R-fMRI) studies have used functional connections as discriminative features for machine learning to identify patients with brain diseases. However, it remains unclear which functional connections could serve as highly discriminative features to realize the classification of autism spectrum disorder (ASD). The aim of this study was to find ASD-related functional connectivity patterns and examine whether these patterns had the potential to provide neuroimaging-based information to clinically assist with the diagnosis of ASD by means of machine learning. We investigated the whole-brain interregional functional connections derived from R-fMRI. Data were acquired from 48 boys with ASD and 50 typically developing age-matched controls at NYU Langone Medical Center from the publicly available Autism Brain Imaging Data Exchange I (ABIDE I) dataset; the ASD-related functional connections identified by the Boruta algorithm were used as the features of support vector machine (SVM) to distinguish patients with ASD from typically developing controls (TDC); a permutation test was performed to assess the classification performance. Approximately, 92.9% of participants were correctly classified by a combined SVM and leave-one-out cross-validation (LOOCV) approach, wherein 95.8% of patients with ASD were correctly identified. The default mode network (DMN) exhibited a relatively high network degree and discriminative power. Eight important brain regions showed a high discriminative power, including the posterior cingulate cortex (PCC) and the ventrolateral prefrontal cortex (vlPFC). Significant correlations were found between the classification scores of several functional connections and ASD symptoms (p &lt; 0.05). This study highlights the important role of DMN in ASD identification. Interregional functional connections might provide useful information for the clinical diagnosis of ASD.

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The putamen is a neural hub which integrates projections from diverse cortical regions and relays to the thalamus and other cortex regions. Numerous studies have reported morphological and functional abnormalities in the putamen. For example, a previous structural magnetic resonance imaging (MRI) study found that participants with ADHD had significantly smaller volume in the putamen than healthy controls. 7 A meta-analysis study has also documented the putamen abnormality in children with ADHD. 8 Abnormal functional connectivity between the putamen and thalamic regions related to spatial working memory processing was observed in ADHD. 9 A resting-state functional MRI (R-fMRI) study observed altered functional connectivity of the putamen in ADHD patients. 10 These studies indicated that the alterations in the putamen may involve ADHD.Granger causality analysis (GCA) is an approach to identify whether the current time series in a brain region or network (X) can be predicted by the past time series of another (Y). GCA

In this paper, route free-flow travel time is taken as the lower bound of route travel time to examine its impacts on budget time and reliability for degradable transportation networks. A truncated probability density distribution with respect to route travel time is proposed and the corresponding travel time budget (TTB) model is derived. The budget time and reliability are compared between TTB models with and without truncated travel time distribution. Under truncated travel time distribution, the risk-averse levels of travelers are adaptive, which are affected by the characteristics of the used routes besides the confidence level of travelers. Then, a TTB-based stochastic user equilibrium (SUE) is developed to model travelers’ route choice behavior. Moreover, its equivalent variational inequality (VI) problem is formulated and a route-based algorithm is used to solve the proposed model. Numerical results indicate that route travel time boundary produces a great influence on decision cost and route choice behavior of travelers.