The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel with thermosensitive sol–gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. Cystic cavities are bridged by fibronectin-rich extracellular matrix. The fibrotic extracellular matrix remodeling is mediated by matrix metalloproteinase-9 expressed in macrophages within the fibrotic extracellular matrix. A poly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts with macrophages via histamine receptors, exhibits substantially diminished bridging effects. I-5 injection improves coordinated locomotion, and this functional recovery is accompanied by preservation of myelinated white matter and motor neurons and an increase in axonal reinnervation of the lumbar motor neurons. Our study demonstrates that dynamic interactions between inflammatory cells and injectable biomaterials can induce beneficial extracellular matrix remodeling to stimulate tissue repair following CNS injuries.
IVietnam, little attention is being paid to the management and treatment of septic tank sludge to take advantage of the number of nutrients in this available resource. This paper presents the potentials and performance of the compost production on the mixing of septic tank sludge and agricultural residues as coffee husk, coconut husk, peat. It added supplementary by 5% bioproducts of Trichoderma sp and 30 ml of molasses in 45days. The results showed the highest quality compost, being mixes of septic tank sludge and coffee husks with total N = 4.01%, total P = 0.41%, total K2O = 3.68% and accepting for the Vietnam standards of fertilizer regulations, resulted also illustrated that E.coli concentration in septic tank sludge sample decreased 2.5 - 3.3 times compared to the previous sample. The second one, the composting efficiency was surveyed on the growth of green mustard plant during 31 days by basal fertilizing and top dressing of this compost at 10 days. The growth of the green mustard plant showed the high compost efficiency septic tank sludge and coffee husk based on 28.21cm of height and 62.5g / plant weight. Especially, NT4 combining from septic tank waste, coffee husk with chemical fertilizers was a good formula by getting the best result in all treatment by combined of compost and chemical fertilizer was at the top dressing period, seems the high compost efficiency in helping Brassica juncea grow well by growing green mustard, being 31.25cm of height and 95.83g / plant weight.
Sewage sludge after urban wastewater treatment needs to be treated intelligently to get maximum benefits. This study proposes a method of anaerobic co-degradation of agricultural sludge and residues to both solve environmental problems and recover a large amount of biogas and organic fertilizers. The results show the potential for energy recovery from biogas and impact assessment of the application directly on the rice fields. It is estimated that biogas recovery from sludge treatment from wastewater treatment plants gives a calorific value of about 76 × 106 MJ/year. Results from the trial crop showed that fertilizer shows good supportability to the plant. The results show that the fertilizer from sewage sludge can be reduced and replaced by 50% to 100% of the number of chemical fertilizers but still give the same yield. The data show that the anaerobic co-digestion method is a suitable method for sludge treatment. The dual objective is to provide valuable benefits from recovered biogas and anaerobic digestion products.
Chemical fertilizers currently poison arable agriculture, so organic fertilizers are now a new trend for soil improvement. This study investigates the appropriate ratio of fertilizer use and materials mixed with sewage sludge in the anaerobic co-digestion treatment method, which will best support agriculture. In the study, bio-organic fertilizer was composted of the co-digestion anaerobic with sewage sludge and agricultural wastes such as rice husk, rice husk charcoal, water hyacinth, cassava peel, and then tested on rice. The specific criteria of fertilizers such as total organic (TOC), total nitrogen (TN), and effective phosphorus (P2O5) and plant growth parameters such as germination rate (%), tillering rate, total weight (g) were evaluated. Initial results show the untreated sludge can be impacted negatively on plant development. The concentration of nutrients in the co-digestion composts was meet the requirements of the Ministry of Agriculture’s standards of organic fertilizer. These bio-fertilizers will play an important role in soil productivity and sustainability. Hence, the widespread use of organic fertilizers from waste to partially replace chemical fertilizers will open up opportunities to reduce farming costs for farmers and develop agriculture sustainably.
Textile wastewater is one of the most water polluted sources affecting the environment, ecosystems, and causing human malignancy because it contains azo dye pigment group. The treatment requires various types of physical and chemical methods which are time-consuming and hazardous environmental effects. The biodegradable method using microorganisms for textile effluent has been applied due to its environmental friendliness and affordability. Our study aims to identify the microorganisms that are capable of simultaneous degradation of three monochromatic colors belonging to the azo dying group, including Congo Red, Methyl Blue, Methyl Orange via qualitative experiments using Potato Dextrose Agar (PDA) media plus the three monochromatic colors and quantitative experiments using Pt-Co calibration curve to identify the biodegradable efficiency of each and combined bacterial isolated strains. The results showed that six bacterial strains isolated from textile waste sludge were capable of decolorizing the three azo - monochromatic pigments. Moreover, we found that strain Bacillus Subtilis E1 owning Quorum Sensing mode had the highest decoloration efficiency with color removal performance for Methyl Orange, Methyl Blue, and Congo Red was 83.7%, 30.6%, and 94.4%. In particular, the combinations of two Bacillus Subtilis strains yielded a multi-color decolorizing performance with an efficiency of over 80% for each pair.
Cassava peel holds an abundance of nutrients that could be utilized as fertilizer in agriculture. However, high cellulose contents make it hard for organic digestion, thus slow down the absorption for plants. In this study, we investigate microorganisms for effective cellulose degradation of cassava peel waste collected directly from Hung Duy Tapioca Starch Factory in Tay Ninh Province, Viet Nam. Experiments evaluate the decrease of mass cassava peel of the two groups of Bacillus - Aspergillus and positive control strains such as Neurospora Crassa. The sample was tested on Czapek - Dox liquid culture medium, a method of assessing the dry mass difference of samples used to assess biodegradability in 28 days. Besides, tests to assess the production of products and environmental parameters such as glucose and pH were recorded. Initial results showed that the combination of Bacillus and Aspergillus provides the highest glucose concentration, reached 16.52 mg/ml and digests 53% of the cassava mass compared with a combination of Neurospora Crassa reached 11.45 mg/ml and 46% of the cassava mass. Comparison results also showed that the action potential of microorganisms was stronger when combined and provided evidence that the formation of combinations of microorganisms would work well in probiotics, which brings better environmental treatment efficiency.
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