A new azo Schiff-base ligand, (N 1 Z,N 2 Z)-N 1 ,N 2-bis(4-((Z)4-hydroxy naphthalen-1-yl)diazenyl)-(1,5-dimethy-2-phenyl-1H-pyrazol-3(2H)-ylidene) benzene-1,2-diamine, has been synthesized from coupling (N 1 Z,N 2 Z)-N 1 ,N 2-bis(4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine with 1-naphthol. Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1 H-NMR), carbon nuclear magnetic resonance (13 C-NMR) technique, ultravioletvisible spectroscopy (UV-Vis), mass analysis, molar conductance and magnetic susceptibility were used to characterize the structures of the new ligand and their transition metal complexes. The complexes were found to have the general formula (M)(L)Cl 2 where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), (M)(L)Cl 3 where M = Au(III), and (M)(L)Cl 2 Cl where M = Fe(III). The FTIR results demonstrated that the coordination sites were the azomethine nitrogen and azo nitrogen atoms of the azo Schiff-base ligand. The electronic spectral and magnetic measurement data indicated that the complexes exhibited octahedral geometry, except the Au(III) complex suggested a square planar geometry around the central metal ion. The results showed the highest inhibitory effect for gold the complex. The effect of biological screening of the gold complex on human colon cancer cell line LS-174 was investigated. The gold complex was observed to have the highest inhibitory effect.
A NEW tetra dentate Schiff base ligand has been synthesized from condensation of compound (1): [(4-((1-H-imidazol-2-yldiazenyl)-1,5-dimethyl-2-phenyl-1Hpyrazol-3(2H)-one)]with compound (2) thio semicarbazaide. The general formula of complexes are [M(L)]Cl 2 Where. M= Co(II) ,Ni (II)and Cu(II)Zn(II) are reported. The geometry structures of ligand and the complexes were determined through Fourier-transform infrared spectroscopy (FT-IR), Mass spectra, X-ray diffraction analysis, Ultra violet-Visible(UV-Vis), Proton nuclear magnetic resonance(1 H NMR) spectral studies, magnetic moment measurement, elemental analysis, and molar conductance. These studies revealed square planar geometries for Ni(II) and Co(II) and Cu(II)complexes, except the Zn(II) complex was a tetrahedral geometry around the central metal ion. Complex formation studies via molar ratio and continuous variation methods were consisted to those found in the solid complexes with a ratio of (M:L) as (1:1). Stability constant of complexes were calculated by spectrophotometric methods. Hyper Chem-8 program has been used to predict geometries structures of compounds in gas phase. The heat of formation (∆H f) and binding energy (∆E b) at 298 K for the metal complexes were calculated by PM 3 method. Biological activity studies of the ligand and their metal complexes against several organisms, bacteria Gram positive G(+ve)staphylococcus aureus and bacteria Gram negative G (-ve)Escherichia coli, klebsiella pneumonic, In addition to fungi like Aspergillus Niger, Rhizoclonia bataicola and Aspergillus flavus , are reported. Compounds exhibited the high activity on the growth of all types microorganisms in this study. This may be attributed to the impact of both the chelate effect of Schiff bases ligand and the role of the metal in these complexes.
The Aim: Biological studies carried out of new gold complexes after its preparation. Place and Duration of Study: All preparations were carried out in college of education, chemistry lab between (Jan 2021 to May 2022). Study Design: New azo –Schiff base ligand 2-amino-3-(2-((3-((2-hydroxy-4-sulfamoylphenyl)imino)-1,5- dimethyl- 2-phenyl- 2,3-dihydro- 1H-pyrazol-4-yl) diazenyl) -1H-imidazol-4-yl)propanoic acid with chelate complexes of Co(II),Ni(II), Cu(II), Zn(II), Cd(II) , Hg(II) and Au(III) were prepared with metal salts in ethanol a solvent in 1:1 ratio (metal : ligand) . The azo-Schiff base ligand has been synthesized from condensation of 2-amino-3- (2-((3-( (2 -hydroxy- 4-sulfamoylphenyl) imino)- 1,5-dimethyl -2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)diazenyl)-1H-imidazol-4-yl)propanoic acid with 4-amino-3-hydroxybenzenesulfonamide. Methodology: The prepared azo Schiff ligand and its metal complexes where checked by different spectral technique as, FT-IR ,C.H.N elemental analyses , Atomic absorption, magnetic moment measurements, molar conductance, UV-vis, ,1H-NMR and mass spectra studies. Results: The data show that the complexes have the composition of 1:1[M:L] chelates type and octahedral geometry with each of Co(II), Ni(II),Cu(II),Zn(II), Cd(II) and Hg(II) ions, except for Au(III) ion which has square planer geometry. All complexes that non electrolytes and no conductive species but Au(III) complex is 1:2 electrolyte nature. This can support the electrolytic nature of the metal complex. Conclusion: Biological activity studies of the ligand and their metal complexes against several organisms, bacteria Gram positive G(+ve)staphylococcus aureus and bacteria Gram negative G (- ve)Escherichia coli, In addition to fungi like Aspergillus Niger, and Aspergillus flavus , are reported. Compounds exhibited the high activity on the growth of all types microorganisms in this study . The results showed the highest inhibitory effect for gold the complex. The effect of biological screening of the gold complex on human colon cancer cell line HT- 29 was investigated. The gold complex was observed to have the highest inhibitory effect.
Weather forecasting is an important issue in meteorology and scientific research.In this research, the Seasonal Auto Regressive.Integrated Moving Average.(ARIMA) model which is based on Box-Jenkins method was adopted to build the forecasting model. The max. Monthly temperature data for Kerbala city for the period (Jan.1980 to Dec.2016) was employed. The autocorrelation and partial autocorrelation functions for time series data from years 1980 to 2015 were used to identify the most appropriate orders of the ARIMA models. The validation test of these models were performed using the monthly max. Temperature of the year 2016. To calculate the model's accuracy and compare among them, statistical criteria such as MAE, RMSE, MAPE, and R2 were used. The model (2, 1, 2) × (1, 1, 1)12 gave the most accurate results and used to forecast the monthly max. Temperature for the period (2017 to 2021) for study region.
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