Background:Lauha Bhasma (LB) is a complex herbomineral preparation widely used as an Ayurvedic hematinic agent. It is an effective remedy for chronic fever (jīrṇa jvara), phthisis (kṣaya), Breathlessness (śvāsa) etc., and possesses vitality enhancing (vājīkara), strength promoting and anti aging (rasāyana) properties.Objectives:The present work was conducted to establish the safety aspects of the use of Lauha bhasma.Setting and Design:LB was prepared by Ayurvedic procedures of purification (śodhana), sun drying (bhānupāka), sthālīpāka, followed by repeated calcination (māraṇa) and “nectarization” (amṛtīkaraṇa). The resultant product was subjected to acute and sub acute toxicity studies.Materials and Methods:Acute and subacute toxicity study of LB was conducted in albino rats. Criteria for assessment included ponderal changes, change in biochemical parameters viz., LFT and KFT and hematological parameters. Histopathological studies of different organs including liver, kidney, spleen, testis etc., were also conducted to observe pathological changes if any.Results:In the acute toxicity study, the animal group did not manifest any signs of toxicity and no mortality was observed up to 100 times the therapeutic dose (TD). Significant increase in blood urea (27.83%, P < 0.01), serum creatinine (30.92%, P < 0.05), Aspartate aminotransferase (15.09%, P < 0.05), and serum alkaline phosphatase (27.5%, P < 0.01) was evident in group IV (10 TD). A significant increase in serum total protein (6.04%, P < 0.05) level was observed in group III (5 TD). Histopathological examination of livers in group IV (10 TD) showed mild inflammation in terms of bile stasis, peri-portal hepatic inflammation and sinusoidal congestion; lymphocyte infiltration in kidney and intracellular deposits in the splenic tissue.Conclusion:Lauha Bhasma was found to be safe at the therapeutic dose and also at five times the therapeutic dose levels. However, alteration in some of the biochemical and haematological parameters along with histopathological findings were evident at the highest dose level.
This study was a single blind open non randomized comparative prospective clinical trial as per the ethical guidelines of Declaration of Helsinki. 30 patients of Iron Deficiency Anaemia were included in this study. This study was conducted to evaluate the therapeutic potential of different Iron containing Ayurvedic formulations viz. Lauha bhasma, Navayasa lauha and Lohasava in comparison to ferrous sulphate. The trial was for a period of 6 weeks and assessment was done on the basis of peripheral blood picture, haematological changes as well as changes observed in biochemical parameters viz. Serum Iron and Total Iron binding capacity. The result of the study revealed that all the three iron containing preparations are effective in the correction of Anaemia. Out of all three trial drugs, Navayasa lauha and Lohasava are found effective haemetenic preparations even better than conventional iron therapy. Further, correction of Serum Iron and Total Iron binding capacity is indicative of their direct role on body Iron store
Rasa Shastra is a branch of Indian iatrochemistry which deals with the processing of metals and minerals having therapeutic importance. Various pharmaceutical procedures i.e. Shodhana (Purification), Marana (Incineration), Satvapatana (Extraction of metal from mineral), Amritikarana (Nectorization) etc. converts deadly toxic substances in to safe and potent therapeutic agent. Ayurvedic classics claimed that Satva Bhasma of any mineral is ten times more potent therapeutically in comparison to its parent mineral Bhasma. Conceivably due to complicated pharmaceutical procedure of Satvapatana and their conversion in to Bhasma, practice of Satva Bhasma in therapeutics is very limited. Rasa Scholars have developed number of methods for Satva extraction and Satva Marana. It is necessary to find out the standard manufacturing procedure (SMP) for Satva extraction and Satva Marana which ensures the quality, safety, efficacy and reproducibility of the products for their global acceptability. This paper aims to make available SMP of Makshika Satvapatana and Satva Bhasma. Shodhana was done by roasting raw Swarna Makshika with lemon juice for three days. Tankana was found advantageous as flux in Satvapatana process of Makshika. Kajjali as a Marana media and four Puta with six kg cow dung cakes were required to get genuine Makshika Satva Bhasma.
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