No abstract

The forced vital capacity (FVC), forced expiratory volume in one second (FEV), and ratio of FEV to FVC (%FEV) of 161 male and 158 female youths of European ancestry who were born at high altitudes and who were residing in La Paz, Bolivia (average altitude of 3,600 m) were examined and compared with those for lowland Europeans and highland Aymara Amerindians. FVC and FEV were significantly larger (p less than .001) in the La Paz Europeans than in two lowland control samples of European ancestry, with the relative differences between samples varying from small (1.5-4.1%) to moderate (7.7-11.9%). It could not be determined whether the enhanced lung volumes of the La Paz European children were acquired through an accelerated development of lung volumes relative to stature during adolescence, as is the case for Amerindian highlanders. After controlling for body and chest size, FVC and FEV were significantly smaller in the La Paz Europeans than in highland Aymara (p less than .001), suggesting that the lung volumes of the Aymara are influenced by factors other than simply growth and development at high altitude. Finally, as found in Amerindians, chest size is an important determinant of intra-individual variation in lung function among highland Europeans.

The physical growth of urban Aymara children residing in La Paz, Bolivia (3,600 m) is described and compared with Amerindian children residing at low and high altitudes and with low-altitude U.S. children. The sample consists of 227 males (10.6-19.7 yr) and 219 females (11.2-19.8 yr). The urban La Paz children were taller at all ages than rural high altitude Amerindian children but similar in stature to urban high altitude children from Peru. The variation in stature among the high altitude populations was considerable, amounting to average differences between the tallest and shortest samples of about 10 cm in males and 8 cm in females. In addition, stature in the two urban high altitude samples was similar to that of rural low-altitude Amerindians. This overlapping of the distributions of stature in high- and low-altitude populations could easily confound comparisons designed to determine the effects of hypoxia on physical growth. La Paz Aymara children had considerably smaller chest sizes relative to stature than high-altitude Quechua children. However, the available data indicates that relative chest sizes are similar in Aymara and Quechua adults, suggesting that the process by which large chests are achieved may differ between these Andean populations.

The developmental adaptation hypothesis (DAH) proposes that highlanders adapt to their hypobaric hypoxic environment during growth and development. This report utilizes data on children (9.0-19.9 yr) of European ancestry residing in Santa Cruz and La Paz, Bolivia, to test selected aspects of the DAH. Previous tests of this hypothesis have been hampered by difficulties in controlling for socioeconomic and genetic influences. However, due to their high socioeconomic status and their relatively short history of residence at high altitudes, these factors can be reasonably well controlled in studies of European children. The data on European children are consistent with some but not all aspects of the DAH. First, examination of the available data on V̇O max (ml/kg/min) in European boys suggests that chronic exposure to hypobaric hypoxia results in an enhancement of the overall functional capacity of the oxygen transport system during adolescence, as predicted by the DAH. Second, chronic exposure to hypobaric hypoxia results in a delay in linear growth and maturation in European children, as well as in an enhancement of their lung volumes, also as predicted by the DAH. However, the effects of chronic hypoxia on linear growth, after controlling for health and nutritional status, are not as large as previously believed and, contrary to the expectations of the DAH, they need not be acquired through a distinctive pattern of growth during late childhood and adolescence. Instead, it appears that these patterns are established in European highlanders prior to 9 years of age and are then maintained, rather than accentuated, during later developmental periods.

Growth and development under conditions of chronic hypoxia result in a different pattern of growth in Andean highlanders than in lowlanders. Growth at high altitude results in a small (1 to 4 cm) delay in linear growth, with most, if not all, of the delay probably established at or soon after birth. It also results in an enhancement of lung volumes, particularly residual volume, which is 70%-80% larger in highland than lowland children, on average, with the magnitude of the increase being positively related to age. In addition, growth and development under conditions of chronic hypoxia result in a blunted ventilatory response to hypoxia, a 4% to 5% reduction in Sa(O2), and a substantial increase in pulmonary diffusing capacity. Andean highlanders have V(O2 max) similar to that of lowlanders at low altitude, suggesting that they have successfully adapted to their hypoxic environment. It is likely that both developmental and genetic factors influence most, if not all, components of the cardiorespiratory system of Andean highlanders, but the relative importance of each is not clear.