Light up my life: Stable, bright, conjugated‐polymer nanoparticles (CPNs) show promise for fluorescence imaging of live cells. The cell‐permeable CPNs are synthesized by a simple solvent exchange, and accumulate exclusively in the cytosol (see picture) without any noticeable inhibition of cell viability.
Fluorescence quenching of poly(phenylene ethynylene) (PPE) particles by a Cy-5 labeled oligonucleotide is 2 orders of magnitude more sensitive than direct excitation of the Cy-5 fluorophore.
Sensitive and reliable monitoring of kinase activity was reported by using highly efficient fluorescence resonance energy transfer of conjugated polymer nanoparticles (CPNs) to a rhodamine labelled peptide substrate.
Stabile, hell leuchtende Nanopartikel aus konjugierten Polymeren (CPNs) sind aussichtsreiche Systeme für die Fluoreszenzbildgebung lebender Zellen. Die zellgängigen CPNs werden durch einfachen Lösungsmittelaustausch synthetisiert und reichern sich ohne merkliche Beeinträchtigung der Zellfunktionen ausschließlich im Cytosol an (siehe Bild).
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