The Mossbauer spectra of the imidazole, pyridine, and piperidine adducts of a"8, , -tetraphenylporphyriniron(II) and protoporphyriniron(II) and the imidazole and pyridine adducts of the corresponding porphyriniron(III) chlorides have been measured. Only the heme compound could be obtained with piperidine because piperidine causes spontaneous reduction of iron(III) to iron(II) in porphyrin complexes. For the iron(II) cases, the imidazole and pyridine adducts show similar isomer shifts, while the piperidine adducts have slightly larger isomer shifts. Imidazole gives the smallest quadrupole splitting; piperidine gives the largest. For the iron(III) cases, imidazole gives a somewhat larger isomer shift than pyridine and causes a much greater quadrupole splitting than pyridine, in contrast to the iron(II) cases. These results are discussed in terms of differences in x-bcmding characteristics between the added ligand and the iron atom. Pyridine appears to have a greater affinity for heme than does piperidine.

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Background-A left bundle-branch block (LBBB)-like pattern with a dominant S-wave in V 1 is common in idiopathic ventricular arrhythmias (VA). Discrimination between idiopathic and scar-related LBBB pattern VA has important clinical implications. We hypothesized that the VA QRS morphology is influenced by the presence of ventricular scar, allowing ECG discrimination of VA arising from structurally normal versus scarred myocardium. Methods and Results-Twelve-lead ECGs of 297 LBBB pattern monomorphic VA were recorded during catheter ablation procedures. QRS morphology characteristics associated with scar-related VA were identified in retrospective analysis of 118 LBBB pattern VA (95 scar-related, 23 idiopathic) to develop a stepwise algorithm that was prospectively tested in 179 LBBB pattern VA (120 scar-related, 59 idiopathic). The diagnosis of scar was based on sinus rhythm surface ECG, cardiovascular imaging, and electroanatomic catheter mapping. A precordial transition beyond V 4 , notching of the S-wave downstroke in lead V 1 or V 2 , and a duration from the onset of QRS to the S-nadir in V 1 Ͼ90 ms were independent predictors for scar-related VA. The proposed algorithm classified a VA as scar-related if any of these criteria was met. If none of the criteria was present, a VA was classified as idiopathic. In prospective validation, the algorithm was highly sensitive (96%) and specific (83%) for the identification of scar-related LBBB pattern VA. Conclusions-The QRS morphology of VA is different between scar-related and idiopathic VA. A simple ECG algorithm is sensitive for identifying scar-related LBBB VA, which could be helpful in guiding further evaluation of these patients. (Circ Arrhythm Electrophysiol. 2011;4:486-493.)

Mössbauer spectra were obtained for the following coordination compounds: iron phthalocyanine, ferrocene, iron carbonyl, iron III acetylacetonate, and iron II acetylacetonate dipyridine; for the following complex ion salts iron II trisphenanthroline chloride, iron III EDTA (monosodium salt), iron II EDTA, hemin, ferricium picrate, sodium nitroprusside, and some ferro- and ferricyanides. The isomer shift (relative to stainless steel) for iron II has the value expected for an inorganic ion only for iron II EDTA. In the other complexes the shifts are about 0.4 mm/sec, except ferrocyanide which is near zero. For iron III only hemin and ferricyanide have unusually small isomer shifts. The large negative isomer shift in sodium nitroprusside suggests iron IV. Except for ferrocyanide quadrupole splittings occurred in iron of valence 0, II, and IV and were observed for both spin-paired and spin-unpaired complexes. Splittings varied widely, however not exceeding those for inorganic ferrous salts. Sodium ferricyanide showed an unexpected quadrupole splitting. Other iron III complexes gave broad and unsymmetrical spectra.

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