Cystitis Glandularis of Intestinal type is an uncommon proliferative disorder with metaplastic alteration of the urothelium showing mucous secreting intestinal glands in the urinary bladder. An association of Adenocarcinoma with longstanding intestinal metaplasia of urothelium is controversial. Due to lack of this evidence and prognosis, we report a case of a 16year-old male presenting with dysuria and a space occupying lesion in the bladder masquerading as a tumor mass. Cystoscopy revealed a well-circumscribed irregular nodal growth arising from the anterior wall of the bladder. Transurethral resection of the mass was performed and the histopathology suggested Cystitis Glandularis of Intestinal Type.

A 68-year-old male presents with generalized lymphadenopathy and fever of short duration. Axillary lymph node excision was performed and was sent for histopathological evaluation. Microscopic evaluation of the submitted lymph node revealed diffuse proliferation of intermediate-sized atypical lymphoid cells with round nuclei, irregular membranes, finely dispersed chromatin, and inconspicuous nucleoli. Mitotic figures were frequently seen. Immunohistochemical evaluation revealed diffuse expression of CD20, CD5, CD10, B-cell lymphoma 2 (Bcl2), and B-cell lymphoma 6 (Bcl6). Atypical lymphoid cells were negative for cyclin D1; however, showed diffuse and strong nuclear expression of SOX11. MIB1 proliferation index was high (Ki67: 90%-95%). Based on morphological features and immunohistochemical findings a diagnosis of “cyclin D1 negative aggressive blastoid variant of mantle cell lymphoma (MCL)” was offered. The classic morphology of MCL is seen in 90% of cases, while the remaining (∼10%) are considered as variants. A blastoid variant is an aggressive subtype that can lack expression of CD5 as well as cyclin D1, but instead expresses CD10, Bcl6, and CD23. SOX11 expression is seen in 90% cases of MCL and in almost 100% cases of cyclin D1 negative MCL. The current case highlights the unusual morphologic and aggressive variant of MCL and a significant role of SOX11 in its diagnosis.

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We herein reported a rare case of a patient who developed a spindle cell tumor of the mesentery. A 45 years old female with a previous history of hysterectomy presented with pain in the abdomen for two weeks. CT scan was suggestive of a well-defined solid, enhancing lesion in the right pelvic region and iliac fossa measuring 10.9×13.9×15.1 cm, abutting right ovary, ileocaecal junction, caecum, appendix and rectosigmoid junction (possible differentials) are right ovarian neoplastic lesion or desmoid tumor. The patient was planned for surgery underwent laparotomy, where the mass appeared to originate from the mesentery (15×12) in dimensions and was adherent to distal ileum and caecum. The mass was inseparable, hence, the right quadra colectomy was taken and the whole mass with distal ileum and caecum and right colon was excised and ileocolic anastomosis was done. The tumor was histologically diagnosed as a spindle cell tumor. Follow up of the patient had been uneventful.