Intestinal Type of cystitis glandularis mimicking bladder tumor- case report and review of literature

Abstract

Cystitis Glandularis of Intestinal type is an uncommon proliferative disorder with metaplastic alteration of the urothelium showing mucous secreting intestinal glands in the urinary bladder. An association of Adenocarcinoma with longstanding intestinal metaplasia of urothelium is controversial. Due to lack of this evidence and prognosis, we report a case of a 16year-old male presenting with dysuria and a space occupying lesion in the bladder masquerading as a tumor mass. Cystoscopy revealed a well-circumscribed irregular nodal growth arising from the anterior wall of the bladder. Transurethral resection of the mass was performed and the histopathology suggested Cystitis Glandularis of Intestinal Type.

Cystitis Glandularis with Intestinal Metaplasia

“…Cystitis glandularis is a epithelial lesion which shows a male preponderance, with peak incidence in the age of 50 years [1]. However, our patient is a female who presented at the age of 37 years.…”

“…In 1761, Morgagni first described cystitis glandularis as a benign proliferative disorder of the bladder for which the pathogenesis was thought to be either congenital due to partial origin of the bladder from embryonal cloaca or due to longstanding irritation causing metaplasia of the urothelium [1].…”

“…Two types of cystitis glandularis have been identified on microscopy -the usual type and intestinal type. Cystitis glandularis of intestinal type is a relatively rare condition and has often been misdiagnosed as bladder tumour [1]. With similar clinical features as other bladder tumours, it has an unclear pathogenesis and its role as a precursor of adenocarcinoma has long been debated.…”