The reactivity of the enamino compounds 4‐amino‐3‐phenylamino(thio)carbonyl‐3‐penten‐2‐one 1 and 2 and ethyl 3‐amino‐2‐phenylamino(thio)carbonyl‐2‐butyrate 7 and 8 was studied using the reaction with hydrazine hydrate and hydrazine hydrochloride to evaluate the 1,3 electrophilic center of the compounds by the formation of the pyrazole rings. The pyrazoles 3, 4, 5, 9, 11 and 13 were obtained depending on the reaction conditions employed.
Reactivity of α-Acylated β-Enamino Ketones and Esters: Synthesis of Pyrazoles.-The reaction of the title ketones such as (I) and (V) and esters such as (VII) and (IX) with hydrazine is investigated. Different kinds of pyrazoles depending on the reaction conditions are obtained. -(MISSIO, L. J.; BRAIBANTE, H. S.; BRAIBANTE, M. E. F.; J.
Preparation of (R)-and (S)-γ-Valerolactone. -Lipase-catalyzed lactonization of racemic phenylseleno esters such as (V) provides access to both (R)-and (S)-enantiomers of phenylselenolactones (III), which can be easily transformed into corresponding γ-valerolactones (VI) via hydride reduction. -(CLOSOSKI, G. C.; COSTA, C. E.; MISSIO, L. J.; CASS, Q. B.; COMASSETO*, J. V.; Synth. Commun. 34 (2004) 5, 817-828; Inst. Quim., Univ. Sao Paulo, 05599 Sao Paulo, Brazil; Eng.) -R. Staver 31-103
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