Enzymatic Resolution of 5‐Phenylselanyltetrahydro‐2‐furanone. Enantioselective Preparation of (R)‐ and (S)‐γ‐Valerolactone.

Abstract

Preparation of (R)-and (S)-γ-Valerolactone. -Lipase-catalyzed lactonization of racemic phenylseleno esters such as (V) provides access to both (R)-and (S)-enantiomers of phenylselenolactones (III), which can be easily transformed into corresponding γ-valerolactones (VI) via hydride reduction. -(CLOSOSKI, G. C.; COSTA, C. E.; MISSIO, L. J.; CASS, Q. B.; COMASSETO*, J. V.; Synth. Commun. 34 (2004) 5, 817-828; Inst. Quim., Univ. Sao Paulo, 05599 Sao Paulo, Brazil; Eng.) -R. Staver 31-103