International audienceThe dramatic effect of morphogenetic protein 2 (BMP-2), presented to cells in a "matrix bound" manner is described. BMP-2 is either delivered in solution or bound to a thin film made of poly(lysine) and hyaluronan. In this later case only, a striking effect of BMP-2 on cell adhesion and migration is observed

Matrix-bound BMP-2 is sufficient to induce β3 integrin–dependent, Cdc42/Src/FAK/ILK-mediated cell spreading by overriding the stiffness response through actin and adhesion site dynamics, showing BMP receptors and integrins work together to control signaling and tensional homeostasis, thereby coupling cell adhesion and fate commitment.