In absence of red blood cells disease or immune defect, parvovirus B19 (PVB‐19) is usually considered as a benign condition. Here, we report the case of a 10‐year‐old boy, previously healthy, presenting with a PVB‐19 infection revealed by a bicytopenia and a voluminous axillary adenopathy. Pathophysiology examination showed reactional lymphoid population. Nine months later and in the absence of remission, a new biopsy of the same adenopathy revealed a Hodgkin lymphoma with area of T‐cell rich aggressive large B‐cell lymphoma. This case suggests PVB‐19 as potential trigger of this malignant childhood hemopathy. Although no definitive conclusion can be drawn, our clinical case questions the role of PVB‐19 in lymphomagenesis.
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