Aggressive large B‐cell lymphoma triggered by a parvovirus B19 infection in a previously healthy child

Abstract

In absence of red blood cells disease or immune defect, parvovirus B19 (PVB‐19) is usually considered as a benign condition. Here, we report the case of a 10‐year‐old boy, previously healthy, presenting with a PVB‐19 infection revealed by a bicytopenia and a voluminous axillary adenopathy. Pathophysiology examination showed reactional lymphoid population. Nine months later and in the absence of remission, a new biopsy of the same adenopathy revealed a Hodgkin lymphoma with area of T‐cell rich aggressive large B‐cell lymphoma. This case suggests PVB‐19 as potential trigger of this malignant childhood hemopathy. Although no definitive conclusion can be drawn, our clinical case questions the role of PVB‐19 in lymphomagenesis.

Sero-prevalence of human Parvovirus B19 Antibodies in Acute Leukaemia Patients of Suez Canal University Hospital

“…Table (2) shows that IgM antibodies against human parvovirus B19 have been detected in 17 of the acute leukemia patients within the study group; these patients also have a high leukocytic count , a decreased hemoglobin level (5-7), a decreased platelet count (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), and a high presence of blast cells (35-65); also, 67.7% of these leukemia patients have received blood or platelet transfusions during their treatment.…”

“…Human cancer might develop as a result of viral infection by oncoviruses including human T-cell lymphotropic virus, Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human papillomaviruses, Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8), and Merkel cell polyomavirus, several distinct aspects of human parvovirus B19 life cycle resemble that of oncoviruses, also there are many recognized parvoviruses which causes cancer and considered oncolytic viruses like the rat parvovirus H-1 [17], [18], [19], [20].…”

Parvovirus B19-viremia. Clinical and laboratory presentation

“…(2019) фіксува ли анемію середньоважкого ступеня як у дітей, так і у дорослих, у 46% хворих різного вікового діапазону. Але у пацієнтів із фоновими гемато логічними захворюваннями чи імунодефіцита ми інфікування PVB19 може спричиняти еритроїдну аплазію із трансфузійною підтрим кою [10,47,48,58,59,63,68,71,72]. N. Claver ISSN 2663 7553 Сучасна педіатрія.…”

“…Є достатньо доказів про зв'язок між PVB19 та численними автоімунними захворюваннями, такими як системний червоний вовчак [4,54,56], ЮРА [17], дерматоміозит [47,48], інтенстиційне ураження легень [6]. Проте на сьогодні немає досліджень, які б продемон стрували його роль у розвитку цих захворю вань.…”