During the last decade, different studies have converged to evidence the high
prevalence of comorbidities in subjects with psoriasis. Although a causal
relation has not been fully elucidated, genetic relation, inflammatory pathways
and/or common environmental factors appear to be underlying the development of
psoriasis and the metabolic comorbidities. The concept of psoriasis as a
systemic disease directed the attention of the scientific community in order to
investigate the extent to which therapeutic interventions influence the onset
and evolution of the most prevalent comorbidities in patients with psoriasis.
This study presents scientific evidence of the influence of immunobiological
treatments for psoriasis available in Brazil (infliximab, adalimumab, etanercept
and ustekinumab) on the main comorbidities related to psoriasis. It highlights
the importance of the inflammatory burden on the clinical outcome of patients,
not only on disease activity, but also on the comorbidities. In this sense,
systemic treatments, whether immunobiologicals or classic, can play a critical
role to effectively control the inflammatory burden in psoriatic patients.
Acute generalized exanthematous pustulosis (AGEP) is an acute febrile rash,
usually induced by drugs, which recently has been linked to spider bite. We
report a case of a male patient, 48 years old, with an erythematous rash
accompanied by fever and small non-follicular pustules. He reported previous
pain in the buttock with the onset of a necrotic plaque. The lesion was
compatible with spider bite of the genus Loxosceles. According to the EuroSCAR
group instrument, the patient scored +10 indicating definite diagnosis of AGEP.
As the patient had a compatible lesion and had no other triggers of AGEP, in an
Loxosceles endemic area, the AGEP would be associated with spider bite, as
described in other publications.
A case of exuberant pretibial mucinosis in a patient with normal thyroid function
is reported. A review of literature on possible etiologies other than thyroid
disease for the accumulation of mucin in the pretibial area is presented. In the
patient described, it is possible that vascular insufficiency is involved.
However, this is not the only factor responsible for the accumulation of mucin,
since there are still unidentified causes and many patients with vascular
diseases do not develop similar injuries.
Objective: according to the epidemiologic and antimicrobial resistance profile, infections are usually classified as community-acquired or nosocomial. Reports on patients without the classic criteria for nosocomial infection with multidrug--resistant germs are increasing. There is a particular concern regarding which microbiological profile must be addressed in case of infections in healthcare workers. This study was carried out with the purpose of identifying the prevalence of infection by multidrug-resistant germs in healthcare workers exposed to occupational contact with such germs at work. Methods: observational and retrospective study. In a 7-year period, healthcare worker hospitalizations were identified and the cultures results were assessed in order to identify the prevalence of infection by multidrug-resistant pathogens. Results: 1,487 healthcare workers hospitalizations were identified. In 105 of these hospitalizations, cultures were collected on the first 5 days after admission, and in 22 patients, 24 germs were identified. Multidrug-resistant pathogens were not found. Conclusion: in our sample, composed of workers from a tertiary public hospital who were hospitalized, none of the individuals presented MDR colonization or infection. These results suggest that when healthcare workers present infections, they must receive antibiotic therapy directed to community-acquired pathogens. In light of the limitations of this study, further larger and multicenter studies must be developed to enlighten such issue.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.