Background: Ototoxicity is a common disabling side effect of
platinum-based chemotherapy. This study aimed to systematically assess
the evidence on the management of platinum-induced ototoxicity in adult
cancer patients. Methods: Three databases were searched up to
November 1, 2022. Original studies were included if they reported on a
pharmacologic or non-pharmacologic intervention to prevent or treat
platinum ototoxicity in adults. The articles’ quality was assessed with
two grading scales. Results: Eighteen randomized controlled
trials and five quasi-experimental studies with 1673 patients were
analyzed. Eleven interventions were identified, nine pharmacological and
two non-pharmacological. Six of the interventions (sodium thiosulfate,
corticoids, sertraline, statins, multivitamins, and D-methionine) showed
mild benefit preventing cisplatin-induced ototoxicity. The data must be
carefully analyzed due to the low quality and underreporting of side
effects. Conclusions: Current interventions have mild benefits
preventing cisplatin-induced ototoxicity in adult cancer patients.
High-quality research is required to clarify the significance of these
findings.
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