Key Points Routine staging by PET-CT identifies all clinically relevant marrow involvement by DLBCL. Cases with marrow involvement identified by PET-CT have PFS and overall survival similar to stage IV cases without marrow involvement.

Intravenous iron therapy is a useful treatment for the rapid correction of iron deficiency anaemia and can be used to avoid or reduce the requirement for allogeneic blood transfusion. Several intravenous iron preparations are available commercially which differ in cost, mode of administration and side effect profile. There are few data directly comparing the efficacy of these preparations. In this retrospective single-centre study, we present the results from two hundred and eight patients treated using three different iron preparations (iron dextran, iron sucrose and ferric carboxymaltose) and compare the effect on haemoglobin levels and other measures of iron deficiency six weeks after treatment. Within the limitations of our study design, we show a statistically and clinically significant difference in efficacy between these preparations.

The paper traces the psychoanalytic networks of the English botanist, A.G. Tansley, a patient of Freud's (1922-1924), whose detour from ecology to psychoanalysis staked out a path which became emblematic for his generation. Tansley acted as the hinge between two networks of men dedicated to the study of psychoanalysis: a Cambridge psychoanalytic discussion group consisting of Tansley, John Rickman, Lionel Penrose, Frank Ramsey, Harold Jeffreys and James Strachey; and a network of field scientists which included Harry Godwin, E. Pickworth Farrow and C.C. Fagg. Drawing on unpublished letters written by Freud and on unpublished manuscripts, the authors detail the varied life paths of these psychoanalytic allies, focusing primarily on the 1920s when psychoanalysis in England was open to committed scientific enthusiasts, before the development of training requirements narrowed down what counted as a psychoanalytic community.

In reconfigurations of the ‘nature’ of the English child and childhood in the early 20th century a key role was played by the Malting House Garden School in Cambridge, England, founded by the unorthodox trader and inventor Geoffrey Pyke and codirected by pioneer educator and psychoanalyst Susan Isaacs. Known scurrilously in the town of Cambridge as ‘a pregenital brothel’, the Malting House School was supported by ecologist A G Tansley and psychologist Jean Piaget amongst others for its ‘copious and careful record of phenomena’. Though short lived, the Malting House School experiment became widely known through popular and influential books, written by Isaacs on early childhood development and education, based largely on data collected at the school. Less is known concerning Pyke's applications of psychoanalytic knowledge, his powerful scientific networks, and his grand vision for a new form of education. With recently recovered records and other archival documents, I seek to contribute to a historical geography of localized psychoanalytic knowledge by exploring the tangle of disciplinary relations in the mutual and imaginative constitution of two pillars of the Malting House School: natural science and psychoanalysis. In particular, I examine what Isaacs referred to as ‘the ecological point of view’ as well as the place of hatred in relation to the nursery school's attempted manufacture of infant scientists eager to ‘find out’. For Pyke, the main threat to the “vigorous survival of an intelligent bourgeoisie” was the Oedipus situation, as described by Sigmund Freud. Through new educational techniques that recognized powerful emotion between generations, Pyke sought to help mould a race that would be able to survive the great changes which he expected science to create in our environment.

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