Comparative Efficacy of Three Forms of Parenteral Iron

Abstract

Intravenous iron therapy is a useful treatment for the rapid correction of iron deficiency anaemia and can be used to avoid or reduce the requirement for allogeneic blood transfusion. Several intravenous iron preparations are available commercially which differ in cost, mode of administration and side effect profile. There are few data directly comparing the efficacy of these preparations. In this retrospective single-centre study, we present the results from two hundred and eight patients treated using three different iron preparations (iron dextran, iron sucrose and ferric carboxymaltose) and compare the effect on haemoglobin levels and other measures of iron deficiency six weeks after treatment. Within the limitations of our study design, we show a statistically and clinically significant difference in efficacy between these preparations.

Iron Overload Effect on Serum Levels of Glucose, Insulin and HOMA-IR was Ifluenced by the Type of Fat in Female Sprague-Dawley Rats Fed High-Fat-Diets

“…Rats were kept on their respective diet. Iron was supplemented by intraperitonial injections as two doses of iron sucrose: dose1 (Do1); 15 mg/kg body weight (BW) and dose 2(Do2); (75 mg/kg BW), three times per week, for 4 consecutive weeks [25][26][27]. In control group, rats received an equivalent volume of sterile saline After which, rats were sacrificed by chloroform anesthesia, after 12 hours fasting.…”

Drug Prescribing Practice Among Anameic Patients in a Tertiary Care Teaching Hospital

“…Iron dextran had caused adverse effects like hypotension, rashes and Ferric carboxymaltose caused urticarial rashes shortly after infusion. [10] Management of anaemia is by iron supplements. Iron tablets have side effects like abdominal pain, constipation or diarrhea, heart burn, feeling sick and black stools.…”

Experimental animal model to study iron overload and iron chelation and review of other such models

“…Many studies discussed earlier used iron dextran. We used iron sucrose based on a study by Dillon et al in 2012 which compares iron dextran with iron sucrose as a source of intravenous iron therapy [41].…”