There is a common relation both in children and adults between OBP and ABP. It is only because high OBP is common in the elderly, and the lowest OBP is usually found in young children that large positive OBP-ABP differences have been associated with old age, and negative differences with childhood. OBP-ABP differences, often defined as white-coat effect, can have different directions and are likely to be largely due to regression to the mean.

Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and PRP (L-PRP) composition on bone defect healing.Materials and Methods: L-PRPs were prepared using different centrifugation methods and their regenerative potential was assessed in an in-vivo rat model. Bilateral critical-size tibial bone defects were created and filled with single-spin L-PRP, double-spin L-PRP, or filtered L-PRP. Empty defects and defects treated with collagen scaffolds served as controls. Rats were euthanized after 2 weeks, and their tibias were collected and analysed using micro-CT and histology.Results: Double-spin L-PRP contained higher concentrations of platelets than singlespin L-PRP and filtered L-PRP. Filtration of single-spin L-PRP resulted in lower concentrations of minerals and metabolites. In vivo, double-spin L-PRP improved bone

The coexistence of an atrial septal defect and a prominent eustachian valve is a rare congenital anomaly, rarely reported in literature. Differentiation between a giant eustachian valve and cor triatriatum dexter can be difficult. A case of a large atrial septal defect associated with cor triatriatum dexter diagnosed by echocardiography in an asymptomatic woman is reported. A watchful waiting strategy was adopted.

Objective: To evaluate new indices, derived from ambulatory BP variability, for associations with clinical characteristics and survival.Design and Methods: Correlation and outcome analyses of an ABPM database. BP variability (BPV), was defined as the weighted average of awake and sleep SD of BP. The following were defined using systolic (SDs) and diastolic (SDd) BPV: BP Variability Ratio (BPVR), defined as SDs/SDd, estimates the slope of the systolic-vs-diastolic pressure relationship using symmetric regression (the corresponding symmetric Ambulatory Arterial Stiffness Index is 1-1/BPVR); dV = SDs2-SDd2; U = (SDs-SDd)SDs; and dS/PP = (SDs-SDd)/PP, where PP is the pulse pressure.Results: Between 1991 and 2009, 4690 patients (age 55 AE 16 years; 52% women) underwent ABPM. 58% were treated for hypertension and 9% for diabetes. Ambulatory BP was 137 AE 16/79 AE 10 mmHg, and BPV was 13 AE 4/ 9 AE 2 mmHg. The median values (and IQR) of the variability-derived indices were: BPVR 1.36 (1.15-1.61); dS/PP 0.057 (0.027-0.090); U 37 mmHg2 (14-79); and dV 64 mmHg2 (26-128). BPVR and dS/PP were more dependent on age and hypertension treatment status compared to U, dV and BPV, but less dependent on gender and systolic BP. BPVR and dS/PP were entirely

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