Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the safety of concomitant PPI use with anti-cancer agents. We aim at reviewing current evidence on this possible interaction by dividing anti-cancer agents by class. Until further data is available, we encourage healthcare providers to limit unnecessary PPI overuse.

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analysis showed the lesion was completely removed with the following characteristics: Below 2.1 mm, vertical growth phase, Clark IV, mitotic index 9/10, no vascular invasion, ulceration present and margins free of malignancy -pT3b; immunopheno type BRAF wild-type. The initial procedure required a wider excision; this was performed two months later and there was no residual