Antibiotics, cancer risk and oncologic treatment efficacy: a practical review of the literature

Lopes, Moises S Martins; Machado, Larissa M; Silva, Pedro Alexandre Ismael Amaral; Uchiyama, Angel Ayumi Tome; Yen, Cheng Tzu; Ricardo, Eliza Dalsasso; Mutão, Taciana Sousa; Pimenta, Jefferson Rios; Shimba, Denis S; Hanriot, Rodrigo de Morais; Peixoto, Renata D’Alpino

doi:10.3332/ecancer.2020.1106

Cited by 6 publications

(1 citation statement)

References 94 publications

(100 reference statements)

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“…Immune surveillance protects the host from endogenous and exogenous threats, including cancer development, infections, and premature aging (Figure 1) (30-34). However, aging and certain medications (antibiotics and antivirals) dysregulate immune surveillance to induce a tumor supportive environment (35)(36)(37)(38)). The immune system-mediated patrolling and monitoring to prevent cancer is called cancer or tumor immunosurveillance (39,40).…”

Section: Immune Surveillance Failure In Cancermentioning

confidence: 99%

Immunometabolic reprogramming, another cancer hallmark

Kumar

Stewart

2023

Front. Immunol.

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Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key biological processes. The complexity of cancer pathogenesis is best illustrated in the six hallmarks of the cancer: (1) the development of self-sufficient growth signals, (2) the emergence of clones that are resistant to apoptosis, (3) resistance to the antigrowth signals, (4) neo-angiogenesis, (5) the invasion of normal tissue or spread to the distant organs, and (6) limitless replicative potential. It also appears that non-resolving inflammation leads to the dysregulation of immune cell metabolism and subsequent cancer progression. The present article delineates immunometabolic reprogramming as a critical hallmark of cancer by linking chronic inflammation and immunosuppression to cancer growth and metastasis. We propose that targeting tumor immunometabolic reprogramming will lead to the design of novel immunotherapeutic approaches to cancer.

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Section: Immune Surveillance Failure In Cancermentioning

confidence: 99%

Immunometabolic reprogramming, another cancer hallmark

Kumar

Stewart

2023

Front. Immunol.

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Antibiotic therapy is associated with an increased incidence of cancer

Roderburg

Loosen

Joerdens

et al. 2022

J Cancer Res Clin Oncol

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Purpose There is a growing body of evidence suggesting the decisive involvement of the human microbiome in cancer development. The consumption of antibiotics may fundamentally change the microbiome and thereby create a precancerous environment promoting cancer development and growth. However, clinical data on the association between the consumption of antibiotics and cancer incidence have remained inconclusive. In this study, we quantified the association between the intake of different antibiotics and various cancer entities among outpatients from Germany. Methods This retrospective case–control study based on the IQVIA Disease Analyzer database included 111,828 cancer patients and 111,828 non-cancer controls who were matched to cancer cases using propensity scores. Patients were categorized as non-users, low-consumption (up to 50th percentile), and high-consumption (above 50th percentile) users of antibiotics overall and for each antibiotic class. Multivariable logistic conditional regression models were used to study the association between antibiotic intake within 5 years prior to the index date (first cancer diagnosis for cases or randomly selected date for controls) and cancer incidence. Results The probability of cancer was significantly higher among patients with a history of antibiotic intake than in matched controls. Patients using penicillin or cephalosporins displayed a higher incidence of cancer, while the intake of tetracyclines and macrolides actually reduced the risk of cancer development slightly. A complex picture was observed in our cancer site-stratified analyses. Most notably, the consumption of penicillin was significantly and positively associated with cancer development in the respiratory organs only (low consumption OR: 1.33, 95% CI 1.20–1.47; high consumption OR 1.42, 95% CI 1.22–1.64) and cephalosporin consumption was significantly associated with respiratory organ cancer (low consumption OR: 1.32, 95% CI 1.17–1.48, high consumption OR: 1.47, 95% CI 1.29–1.66), breast cancer (high consumption OR: 1.40, 95% CI 1.25–1.56), and lymphoid and hematopoietic tissue cancer (high consumption OR: 1.50, 95% CI 1.35–1.66). Conclusion Our data strongly support the hypothesis that the intake of antibiotics is positively associated with the risk of cancer development.

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Redrawing therapeutic boundaries: microbiota and cancer

et al. 2022

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The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host's proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer-microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the microbiota's causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology.

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Antibiotics, cancer risk and oncologic treatment efficacy: a practical review of the literature

Cited by 6 publications

References 94 publications

Immunometabolic reprogramming, another cancer hallmark

Immunometabolic reprogramming, another cancer hallmark

Antibiotic therapy is associated with an increased incidence of cancer

Redrawing therapeutic boundaries: microbiota and cancer

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