Objectives: To evaluate the effectiveness and acceptability of a new vaginal moisturizer composed of a combination of humectants, moisturizers, bioadhesives, and viscosity polymers (sodium hyaluronate 0.1%, polycarbophil 1.5%, carbomer 1.5%, and glycerin 1%) for relief of vulvovaginal symptoms associated with genitourinary syndrome of menopause in Brazilian postmenopausal women. Methods: An open clinical trial was performed with 33 postmenopausal women between 47 and 68 years of age with genitourinary syndrome of menopause symptoms such as vaginal dryness accompanied by pain or discomfort during intercourse. Clinical efficacy in relieving symptoms of genitourinary syndrome of menopause and acceptability were assessed using a Likert scale questionnaire. Efficacy and safety were assessed through gynecological examination, which included visual inspection of the epithelium and vaginal contents, and determination of vaginal pH. Wilcoxon's non-parametric test and paired Student's t-test were used for statistical analyses.Results: After 3 weeks of treatment, most participants reported improvement in GSM symptoms like vaginal dryness (p<0.001), discomfort during or after sexual intercourse (p<0.001), pain during or after sexual intercourse (p<0.001), vaginal odor (p=0.047) and itching (p=0.032) and good acceptability of the moisturizer. There was no alteration in the vaginal health index; however, a reduction in vaginal inflammation (p=0.046) was observed. No clinically significant adverse events were reported by participants. Conclusions: Treatment with non-hormonal vaginal moisturizer for 3 consecutive weeks in postmenopausal women with symptoms of genitourinary syndrome of menopause promoted improvements in vaginal hydration, showing a clinically adequate profile of efficacy and safety, in addition to a satisfactory degree of acceptability.
Introdução: As doenças cardiovasculares representam a maior causa de morte em todo o mundo. Objetivos: Elucidar o estilo de vida de profissionais de uma indústria farmacêutica, avaliando os fatores de risco cardiovascular. Métodos: Estudo observacional, longitudinal e prospectivo, realizado com 1875 indivíduos de ambos os sexos. Além de questionário para identificar o estilo de vida, foi realizado o cálculo do Índice de Massa Corporal, aferição da pressão arterial, coleta de amostra de sangue para dosagem de colesterol total sérico e hemoglobina glicada. Resultados: 83,0% nunca tinham fumado; 48,1% não faziam atividade física regularmente e mulheres tendem a realizar menos atividades físicas do que homens; 57,6% consumiam menos de duas porções de frutas ou verduras por dia; 63,8% consumiam peixe menos de 1 vez por semana; 51,6%consumiam menos de um copo por dia de bebidas com açúcar, sendo que as mulheres consomem menos bebidas açucaradas do que homens. A maioria (43,6%) tinha Índice de Massa Corporal entre 25 e 29,9 m/Kg² ou entre 18,5 e 24,9 m/Kg². A maioria apresentou colesterol total abaixo de 200 mg/dl (75,1%), hemoglobina glicada abaixo de 5,7%, e 47,6% apresentaram pressão arterial sistólica entre 120-139 mmHg e pressão arterial diastólica menor que 80 mmHg (56,1%). Conclusões: Os dados são condizentes com informações de literatura, nos quais fica demostrado que é possível melhorar hábitos como tabagismo, alimentação e prática de atividade física regularmente. Palavras-chave: medicina do trabalho; doenças cardiovasculares; indústria farmacêutica; estilo de vida saudável.
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