Diabetes mellitus (DM) is defined as a group of diseases of metabolic origin resulting from the failure of secretion or action of insulin. It is divided into two main types: type I-related to the autoimmune destruction of pancreatic cells; and type II-related to alteration in production and cellular resistance to insulin (Mealey & Oates, 2006).Regardless of the degree of development of the country, DM is a significant and growing global health problem. In Brazil, the most recent data point to over sixteen million diagnoses, which has led to an
Periodontitis is an inflammatory disease with a multifactorial etiology, triggered by the host's immune-inflammatory response to the periodontopathogens, manly gram-negative bacteria, present in the subgingival biofilm. Systemic conditions, such as diabetes mellitus (DM), can alter this response through immunological and microbiological changes. Studies have shown that DM promotes a dysbiotic pattern of biofilm, which may alter endotoxin content in the subgingival environment. Thus, the present study aims to evaluate the relationship between cytokine profile and lipopolysaccharide levels in the subgingival environment of diabetic and non-diabetic subjects.
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