Anterior pituitaries from "small" (250 g) and "large" (400 g) rats flown on the 7-day Spacelab 3 mission were pooled and trypsinized into two single-cell suspensions. Compared with ground-based controls, flight cells appeared to contain more intracellular growth hormone (GH) but release less GH over a 6-day culture period. After implantation into hypophysectomized rats, both sets of flight cells released only 50% of the GH compared with the control cells. Glands from large flight rats contained 44% somatotrophs compared with 37% for controls; small animals showed no difference. There were no striking differences in somatotroph ultrastructure between cells in the four groups. Western blot analysis indicated that there were no major differences in immunoactive GH variants. High-performance liquid chromatography fractionation of culture media indicated that small flight cells released much less of a high-molecular weight variant rich in GH bioactivity. The results suggest that GH cells from rats exposed to microgravity may experience secretory dysfunction. The possibility that this occurs directly at the pituitary cell level is discussed.
Purpose Role of intravitreal injection of dexamethasone implant (Ozurdex) for refractory macular thickening. Methods A case report of a 13-year-old boy with Rhodopsin-positive, CRB1-negative retinitis pigmentosa presenting with Coat's-like exudative vitreoretinopathy and treatment-resistant cystoid macular oedema. Results A reduction in the macular thickening following a single injection of Ozurdex. Conclusion We present our experience in successful treatment of refractory macular oedema with intravitreal injection of dexamethasone implant resulting in clinically significant resolution of macular thickening.
Introduction: Intertrochanteric femur fracture is one of the most common fractures of the hip especially in the elderly with osteoporotic bones, usually due to trivial trauma. Dynamic Hip Screw (DHS) is still considered the gold standard for treating intertrochanteric fractures by many. Proximal femoral nail is a relatively newer implant designed to treat unstable intertrochanteric fractures. The present study was conducted to evaluate functional outcome in intertrochanteric femur fractures treated by proximal femoral nailing. Methods: The present study is a prospective study performed on 98 patients of intertrochanteric femoral fractures treated by Proximal Femoral Nail (PFN) in department of Orthopedics at Shri Bhausaheb Hire Government Medical College, Dhule. Functional outcome was assessed by modified Harris hip score at the end of 6 months postoperatively. Result: Total 98 patients were included, 32 were females and 66 were males. Age group ranged from 18 to 85 years. Maximum patients (40.81%) were between 60 to 70 yrs age group. 56.12% of patients had Evans type I fracture and the rest (43.87%) had type II fracture. Excellent outcome observed in 30.6% patients, good in 44.9%, fair outcome in 14.2% and only 10.2% had poor outcome among 98 patients. Conclusion: It is concluded from our study that use of PFN for treatment of intertrochanteric fractures provides a good functional outcome along with advantages in terms ofminimal blood loss, early weight bearing and few complications. It is the implant of choice for unstable intertronchanteric fractures.
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