T h e ne w e ngl a nd jou r na l o f m e dicine n engl j med 371;19 nejm.org november 6, 2014 1. Orrú CD, Bongianni M, Tonoli G, et al. A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med 2014;371:519-29. 2. Peden AH, McGuire LI, Appleford NE, et al. Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion.
A 10-wavelength, polarization-multiplexed, monolithically integrated InP transmitter PIC is demonstrated for the first time to operate at 112 Gb/s per wavelength with a coherent receiver PIC.
A 13-month-old female presented with initial complaints of not gaining weight since birth, recurrent vomiting and tonic posture till tenth day of her life. She had a past history of seizures at the age of 6-7 months associated with fever with a frequency of 1-2 episodes per month which lasted till 11 months of age. She was admitted at another tertiary care hospital at the age of 10 months for not gaining weight and was diagnosed with global developmental delay.She was the third child of a second degree consanguineous marriage. Mother's antenatal period was uneventful with proper intake of iron and folate supplementation. The girl was born full term by Lower Segment Caesarean Section (LSCS) in hospital. The birth weight was 1.8 kg, with immediate cry after birth. Breast feeding was started 3-4 hours after birth. The early neonatal period was uneventful. She received complete immunisation with DPT/OPV/ Hep B vaccination.On general physical examination, she was found undernourished with presence of pallor. Her height/weight ratio was less than -3 SD. A differential diagnosis of global developmental delay, sepsis, SAM, iron deficiency anaemia or inborn error of metabolism was made. Then, the child was admitted and started with nasogastric feed.In addition to routine investigations, some special investigations to rule out inborn error of metabolism were also done. High sensitivity C Reactive Protein (Hs-CRP) was 8.89 mg/dl (normal range <1 mg/ dl), plasma ammonia levels was 117.64 µmol/l (normal range 10-
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