Aspergillus is a genus of ubiquitous fungi that are pathologically & therapeutically important. Aspergillus Secondary Metabolites Database (A2MDB) is a curated compendium of information on Aspergillus & its secondary metabolome. A2MDB catalogs 807 unique non-redundantsecondary metabolites derived from 675 Aspergillus species. A2MDB has a compilation of 100 cellular targets of secondary metabolites, 44 secondary metabolic pathways, 150 electron and light microscopy images of various Aspergillus species. A phylogenetic representation of over 2500 strains has been provided. A2MDB presents a detailed chemical information of secondary metabolites and their mycotoxins. Molecular docking models of metabolite-target protein interactions have been put together. A2MDB also has epidemiological data representing Aspergillosis and global occurrence of Aspergillus species. Furthermore a novel classification of Aspergillosis along with 370 case reports with images, were made available. For each metabolite catalogued, external links to related databases have been provided. All this data is available on A2MDB, launched through Indian Institute of Chemical Technology, Hyderabad, India, as an open resource http://www.iictindia.org/A2MDB. We believe A2MDB is of practical relevance to the scientific community that is in pursuit of novel therapeutics.
This paper presents an assessment of the impact of traffic and weather on the likelihood of executing continuous descent operations (CDO) and continuous climb operations (CCO) in a busy multi-airport system. Our analysis of empirical data available for the Houston Metroplex region indicates that increased traffic levels and the presence of traffic management initiatives related to either congestion or weather tend to decrease the likelihood of flights executing both continuous descent and continuous climb operations. The extent to which arrival or departure procedures were used remained the same between flights executing CDOs (or CCOs) and all other flights. We demonstrate this by the use of scatter plots and logistic regression.
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