Aspergillus Secondary Metabolite Database, a resource to understand the Secondary metabolome of Aspergillus genus

Abstract

Aspergillus is a genus of ubiquitous fungi that are pathologically & therapeutically important. Aspergillus Secondary Metabolites Database (A2MDB) is a curated compendium of information on Aspergillus & its secondary metabolome. A2MDB catalogs 807 unique non-redundantsecondary metabolites derived from 675 Aspergillus species. A2MDB has a compilation of 100 cellular targets of secondary metabolites, 44 secondary metabolic pathways, 150 electron and light microscopy images of various Aspergillus species. A phylogenetic representation of over 2500 strains has been provided. A2MDB presents a detailed chemical information of secondary metabolites and their mycotoxins. Molecular docking models of metabolite-target protein interactions have been put together. A2MDB also has epidemiological data representing Aspergillosis and global occurrence of Aspergillus species. Furthermore a novel classification of Aspergillosis along with 370 case reports with images, were made available. For each metabolite catalogued, external links to related databases have been provided. All this data is available on A2MDB, launched through Indian Institute of Chemical Technology, Hyderabad, India, as an open resource http://www.iictindia.org/A2MDB. We believe A2MDB is of practical relevance to the scientific community that is in pursuit of novel therapeutics.

Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – Past, present and future

“…With about 350 accepted species each in Aspergillus [ 2 , 60 ] and Penicillium [ 1 ] and more than 100 accepted species in Talaromyces [ 63 , 89 ], qualitative databases equipped with a large volume of verified data on the production of secondary metabolites by various Aspergillus , Penicillium and Talaromyces species is needed for accurate species identification [ 2 ]. In view of this, an Aspergillus Secondary Metabolites Database (A2MDB) was established last year [ 90 ]. Recently, metabolic fingerprinting has also been demonstrated as a potentially successful tool for differentiating closely related Aspergillus species, without the need of investigating the actual identities of the metabolites.…”

Volatiles from three genome sequenced fungi from the genus Aspergillus

“…Some of these species are human pathogens, e.g., Aspergillus fumigatus can cause infections especially in immunocompromised patients, while other species are safe, e.g., Aspergillus oryzae is traditionally used in Japanese sake brewing. The genus has a rich secondary metabolism with 807 compounds from 675 species that were recently summarised in the Aspergillus secondary metabolome database [ 14 ]. However, only a few studies about volatile natural products from Aspergillus are available [ 15 – 22 ].…”

Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects

“…The fungi of the Aspergillus genus are well known to be a rich source of secondary metabolites with a broad spectrum of biological activities. The Aspergillus Secondary Metabolites Database (A2MDB) had documented 807 unique non-redundant natural products derived from 675 Aspergillus species by 2017 [ 1 ]. A growing amount of evidence also indicates that symbiotic Aspergillus strains are an important contributor of bioactive natural products.…”