There is limited information on the prevalence and pattern of HIV drug-resistant mutations (DRMs) among HIV-1-coinfected tuberculosis (TB) patients before and after antiretroviral treatment. Patients with HIV-1 and TB were recruited into a clinical trial from two different once-daily antiretroviral regimens and followed for a period of 6 months after ART initiation. Patients were treated with standard short-course anti-TB treatment (2EHRZ3/4RH3) and were randomized to receive ddI/3TC with either nevirapine or efavirenz, once daily. Genotypic drug resistance (DR) testing was carried out for the pol gene at baseline and at the time of virological failure. At baseline, major DRMs with respect to NNRTIs (G190GA) and TAMs (T215S and I) were observed in 3 out of 107 patients. Of 15 treatment failures, 14 had more than one major NRTI and NNRTI mutation. V106M was the major NNRTI mutation that emerged in EFZ and Y181C in the NVP group. Among NRTI mutations, M184V was the commonest followed by L74I/V. Primary drug resistance to antiretroviral drugs was low among HIV-1 co-infected TB patients in south India. A once-daily regimen of ddI/3TC/EFZ or NVP results in a specific pattern of NNRTI mutations and negligible thymidine analog mutations (TAMs).

Multi Drug Resistant Tuberculosis (MDR-TB) is an emerging problem of great importance to public health worldwide. Resistance to Rifampicin (RIF) and Isoniazid (INH) are considered as surrogate markers for MDR-TB. Resistance in Mycobacterium tuberculosis to Rifampicin is reported to be conferred by mutation in an 81bp rifampicin resistance determining region (RRDR) of the β subunit of RNA polymerase encoded by rpoB gene corresponding to codons 507-533. Resistance to Isoniazid is conferred by mutation in Catalase-peroxidase gene (katG), alkyl hydroperoxidase gene (aphC) and enoyl acyl reductase gene (inhA). The aim of this study was to identify the mutation conferring resistance to INH and RIF by automated DNA sequencing. Seventy-four isolates of M. tuberculosis were tested phenotypically with four anti tuberculosis drugs namely Rifmapicin (RIF), Isoniazid (INH), Ethambutol (EMB) and Streptomycin(SM) by absolute concentration method. Three isolates from pulmonary tuberculosis (PTB) patients were resistant to RIF with minimum inhibitory concentration (MIC) greater than or equal to 128µg/ml and to INH with MIC greater than are equal to 5µg/ml. The genome of these three MDR-TB isolates were amplified by Polymerase Chain Reaction (PCR) and DNA sequencing was performed. All three isolates showed a point mutation at codon 315 (Ser ® Thr) in the sequenced katG region for INH resistance, but did not show any mutation in the 81bp hotspot sequenced rpoB region for RIF resistance and promoter region of inhA and aphC for INH resistance. Two of three isolates were from patients who had not taken treatment previously which is of great concern with respect to public health.

As chip multiprocessors (CMP) have become eminent in all areas of computing, it is inevitable for the operating system to schedule processes efficiently on different cores. These multi-cores pose different challenges of which shared resource contention is the dominant one, as cores share resources like last level cache (LLC) and main memory. This can lead to poor and unpredictable performance of the threads running on the system. The cache replacement policy of LLC becomes critical in managing the cache data in an efficient way. Though prominent, least recently used (LRU) algorithm has some issues with applications which do not follow the temporal locality pattern. This study proposes a modification to the LRU algorithm where a random selection of the victim from 'N' LRU blocks yields better results than the conventional method. The evaluation of the algorithm is carried out using Multi2sim simulator using Parsec and Splash2 benchmarks. The results show an overall performance improvement in hit ratio up to 6% and 2% over LRU for PARSEC and SPLASH2 benchmarks respectively.

Copper Indium Oxide (CuInO2) nanocrystalline powder samples with different Cu/In ratios were prepared using the conventional solid-state reaction method. The structural, morphological, and optical properties of CuInO2 samples were studied. The delafossite structure of copper indium oxide nanocrystalline samples with (0 1 2) preferential orientation is observed. With altering the composition, the particles size of the prepared powder samples changed ranging from 6 nm to 94 nm, and the energy band gaps varied from 2.20 eV to 2.37 eV. Photoluminescence intensity at 595 nm and 596 nm in the visible region enhanced with variation of Cu/In ratios.

Background: Many primary endocrine disorders have notable effects on cognition. Patients with a wide range of thyroid gland abnormalities often present with combined emotional and cognitive symptoms. Aims and Objectives: To evaluate the cognitive dysfunctions in patients suffering with thyroid disorders. To compare the cognitive dysfunctions in patients with thyroid disorders such as hypothyroidism, hyperthyroidism and subclinical thyroid states. Materials and Methods: A Purposive sampling was undertaken from the outpatient