Now-a-days, the most occurring problem is hair fall, so the main aim of the study is to reduce hair fall and promote hair growth. The main ingredient in this study is fermented rice water (Oryza sativa) which contains many antioxidants when compared to the plain rice water. Inositol is the major constituent which helps in decreasing hair fall. The herbal shampoo was formulated using some of the traditional herbs like Hibiscus-rosa-sinensis, Phyllanthus emblica, Aloe vera, Trigonella foenum graceum along with fermented rice water in different concentrations and evaluated for various parameters. The prepared herbal shampoo was evaluated with physico-chemical parameters like pH, foam formation, dirt dispersion, surface tension, viscosity and wetting test. The results states that the herbal shampoo possess the following characteristics such as good foam ability, good cleansing, low surface tension, viscosity and soothing property. The evaluation results of the herbal shampoo had shown better results, which is ideal to use, safe and effective in the treatment of hair fall. Keywords: Herbal shampoo, Oryza sativa, Hair fall.
This article highlights the comprehensive review of the prospects and impediments to the innovation of orphan drug development. Orphan medications are used to treat rare diseases. Orphan medication products have been one of the fastest-increasing sectors of drug research. Orphan diseases represent an issue for the world's health sector and a chance to concentrate on innovation. Many nations around the world continue to struggle with rare diseases. Several parties must come up with fresh and innovative solutions to assist the millions of people worldwide who suffer from uncommon diseases. To strategically develop their treatments, pharmaceutical industries concentrate on rare diseases and hinge on novel alliances. To accelerate the research and approval of new drugs, regulatory agencies like US FDA and TGA have developed a wide variety of strategies like financial aid. The process of developing an orphan medicine is the same as for common diseases but requires substantial resources and infrastructure. Several nations including the USA and Australia have implemented orphan drug legislation, which successfully advocated research and development for the creation of novel medication used in the treatment of rare disorders. The purpose of orphan drug regulations was to encourage research and development by providing incentives for the creation of drugs that have the potential to cure millions of individuals suffering from rare illnesses. Prospects related to innovation of orphan drug developments like fee waivers, reimbursements, tax credits and market exclusivity and the majority of the impediments are related to orphan drug pricing patterns, the lack of treatment and diagnosis for rare diseases, regulatory constraints, and the approval process. The individual patient is the major focus of the orphan medication market. For example, the majority of the impediments are related to orphan drug pricing patterns, the lack of treatment and diagnosis for rare diseases, regulatory constraints, and the approval process.
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