With the emergence of new and re-emerging viral diseases, scientists have been working to produce new medications with novel targets and pathways. The discovery of safe and efficacious antiviral medicines is critical due to the constant introduction of new virus types and short lifetime of protection. Since the outbreak, there have been significant efforts to repurpose existing and licensed medications for rapid human testing and possible emergency use authorizations. The exploration of surviving medications for new restorative motives is known as drug repurposing. It is a successful, rapid, and highly reliable alternative to traditional drug methods. COVID-19 is being treated using a number of repurposed and new medicines. Molnupiravir is a repurposed Covid-19 medicine that was specifically developed to cure influenza and is used to treat mild to moderately ill Covid-19 patients with high risk of becoming seriously ill. The importance of medication repurposing, as well as the regulatory procedure for repurposed pharmaceuticals and Emergency Use Authorization in the United States, are summarized in this article.
Essential oils have been used for virucidal, bactericidal, fungicidal, antiparasitic, insecticidal, and other therapeutic properties like analgesic, sedative, spasmolytic, anti-inflammatory, and locally anaesthetic remedies since the Medieval Era. Essential oils are complex mixtures of a variety of volatile molecules which includes terpenoids, phenol-derived aromatic components, and aliphatic components. These molecules are used in the pharmacological, cosmetic, sanitary, food, and agricultural sectors for multiple applications. The stability and bioactivity of essential oils, on the other hand, impact their efficacy. The ultrasonication procedure is one of the most effective ways to preserve essential oils. Improved water solubility, effective degradation protection, and the prevention of volatile component evaporation are just a few of the benefits. This article focuses on nanotechnology's most significant contributions to essential oils formulated using the Ultrasonication process. The chemical makeup of essential oils, the Ultrasonication technique's basis, the physicochemical characteristics of nanoformulation loaded with essential oil, and their contemporary uses are all highlighted. Essential oils can perform better than chemically synthesized drugs. As compared to certain other formulation techniques, oil nanoencapsulation has been noted as a cost-effective approach, and the ultrasonication approach is a simpler, less energy-consuming, more repeatable, and broadly valid method for the encapsulation of essential oils.
Registration of pharmaceutical drug products in emerging market is maximum worrying task. Although the requirements are harmonized in regulated international locations by way of CTD (Common technical document) submitting, yet others have considerable diversity in necessities. International conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) has brought regulatory authorities and pharmaceutical industries of US, Japan and Europe collectively for various factors of drug registration. But there is no such harmonized guideline for rising marketplace besides Association of Southeast Asian Nations (ASEAN) and Gulf Co-operation Council (GCC) where harmonization exists in clusters with their mutual situation. Quality, Safety and Efficacy information has significance importance in dossier registration. Pharmaceutical Industries has to conform with regulatory requirement in Emerging market and for betterment of public Health and protection. The business importance of markets is increasing globally. It is important for pharmaceutical enterprise to address the regulatory necessities for betterment of public and to ensure their place in the marketplace. The review additionally explains a short approximately extraordinary regulatory requirement for Registration of drug product in Emerging market and comparative data for registration of dossier software in Emerging marketplace.
The opportunity to successfully develop and roll out patient-centric digital health platforms is represented by Software as a medical device (SaMD).Software is now a crucial component of all products and is widely integrated into digital platforms that are used for medical purposes as technology in all areas of health care continues to progress. Artificial intelligence (AI) is a potent and currently evolving technology that has the potential to enhance capabilities in a wide range of sectors. Medical device companies have been fascinated in artificial intelligence. Nowadays Artificial intelligence based medical devices are gaining a lot of attention. Artificial intelligence-enabled medical devices have the potential to completely transform the way that healthcare is provided by enabling physicians to diagnose and treat their patients more precisely and successfully while also enhancing their overall level of care. The three primary objectives of the medical devices that are incorporated with AI are being developed by medical device companies as technology progresses are chronic disease management, medical imaging and Internet of Things (IoT). Quite apart from its advantages, artificial intelligence in medical devices also has drawbacks, such as the necessity for regulation to keep up with the rate of technological innovation. The softwares such as Eye Art and IDxDR for the identification of diabetic retinopathy, Quant X for breast abnormalities, Gleamer BoneView for fractures on X rays and software for the management of type 1 diabetes i.e., Dreamed Advisor Pro and as well as the AI-ECG platform are just a few instances of the artificial intelligence-infused software’s that are discussed in this article.
The Cefuroxime axetil has been used in treatment of wide range of infections but exhibits poor and variable bioavailability thus it is difficult to establish optimal oral dosage schedule. The purpose of this work was to prepare stable solid self-microemusifying drug delivery system (S-SMEDDS) of cefuroxime to improve the solubility and dissolution. The saturation solubility of drug in oils, solvents, surfactants and co-surfactants were determined and ternary phase diagram was drawn. Based on the results SMEDDS were prepared and characterized for self-emulsification properties and in-vitro dissolution. One of the best SMEDDS formulations was converted to S-SMEDDS by adsorption technique using maltodextrin as adsorbent. SEM of the S-SMEDDS revealed that particles were well separated and were free flowing, characterization by DSC, XRD revealed no interaction between drug and excipients. In-vitro dissolution was rapid and complete and no marked changes in physical and emulsification property were observed on stability.
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