EVAR patients received high radiation doses and the excess cancer risk attributable to radiation exposure is not negligible. The unenhanced scan and the venous phase of the MDCT angiography could have been omitted without compromising the utility of the examination and with a significant reduction of doses and associated risks.
Using about half of the activity recommended by the current diagnostic reference levels for separate-day myocardial perfusion imaging, the present study demonstrates that images may be obtained using ST protocol with quantitative results comparable with those from studies performed using the HT protocol, which is equivalent to an administered activity of 530 MBq. The former protocol would allow for a significant reduction of the dose to the patients as well as to the operators. Further studies are needed to confirm that this dose-sparing approach does not hamper sensitivity and specificity for coronary stenoses.
The purpose of this study was to analyze the behavior of a contouring algorithm for PET images based on adaptive thresholding depending on lesions size and target‐to‐background (TB) ratio under different conditions of image reconstruction parameters. Based on this analysis, the image reconstruction scheme able to maximize the goodness of fit of the thresholding algorithm has been selected. A phantom study employing spherical targets was designed to determine slice‐specific threshold (TS) levels which produce accurate cross‐sectional areas. A wide range of TB ratio was investigated. Multiple regression methods were used to fit the data and to construct algorithms depending both on target cross‐sectional area and TB ratio, using various reconstruction schemes employing a wide range of iteration number and amount of postfiltering Gaussian smoothing. Analysis of covariance was used to test the influence of iteration number and smoothing on threshold determination.The degree of convergence of ordered‐subset expectation maximization (OSEM) algorithms does not influence TS determination. Among these approaches, the OSEM at two iterations and eight subsets with a 6–8 mm post‐reconstruction Gaussian three‐dimensional filter provided the best fit with a coefficient of determination R2=0.90 for cross‐sectional areas ≤ 133 mm
2
and R2=0.95 for cross‐sectional areas > 133 mm
2
. The amount of post‐reconstruction smoothing has been directly incorporated in the adaptive thresholding algorithms. The feasibility of the method was tested in two patients with lymph node FDG accumulation and in five patients using the bladder to mimic an anatomical structure of large size and uniform uptake, with satisfactory results.Slice‐specific adaptive thresholding algorithms look promising as a reproducible method for delineating PET target volumes with good accuracy.PACS numbers: 87.57.nm, 87.55.D‐, 87.57.uk
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.