Five-year experience of quality control for a 3D LSO-based whole-body PET scanner: Results and considerations

Matheoud, Roberta; Goertzen, Andrew L.; Vigna, L.; Ducharme, Jaylene; Sacchetti, Gian Mauro; Brambilla, Marco

doi:10.1016/j.ejmp.2011.07.002

Cited by 13 publications

(13 citation statements)

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“…In PET- and SPECT-based segmentation, an accurate standardization is needed, since SUV is dependent from different factors, like image acquisition and data reconstruction, VOI definition, tracer-specific pathophysiological factors, or the kinetics of tracer distribution. Even in single-center studies, SUV can show relevant variation over the years, as the detectors’ sensitivity dwindles [ 49 ]. Besides, the adoption of a fixed threshold does not in any way ensure a full specificity of the segmented uptake (as SUV of many benign processes overlaps with the metastases-related one) [ 50 ]; increasing this threshold might result in a loss of sensitivity while decreasing it might affect specificity.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

et al. 2018

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Metastasized castration-resistant prostate cancer (mCRPC), is the most advanced form of prostate neoplasia, where massive spread to the skeletal tissue is frequent. Patients with this condition are benefiting from an increasing number of treatment options. However, assessing tumor response in patients with multiple localizations might be challenging. For this reason, many computational approaches have been developed in the last decades to quantify the skeletal tumor burden and treatment response. In this review, we analyzed the progressive development and diffusion of such approaches. A computerized literature search of the PubMed/Medline was conducted, including articles between January 2008 and March 2018. The search was expanded by manually reviewing the reference list of the chosen articles. Thirty-five studies were identified. The number of eligible studies greatly increased over time. Studies could be categorized in the following categories: automated analysis of 2D scans, SUV-based thresholding, hybrid CT- and SUV-based thresholding, and MRI-based thresholding. All methods are discussed in detail. Automated analysis of bone tumor burden in mCRPC is a growing field of research; when choosing the appropriate method of analysis, it is important to consider the possible advantages as well as the limitations thoroughly.

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Section: Resultsmentioning

confidence: 99%

Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

et al. 2018

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“…For personal use only. jnm.snmjournals.org Downloaded from have to be individually established for the scanner used for imaging (27). By omitting any cut-off, our approach does not call for individual adaption and should be independent of scanner features.…”

Section: Early Termination Vs Completed 223ra Treatmentmentioning

confidence: 99%

The Prognostic Value of Quantitative Bone SPECT/CT Before ²²³Ra Treatment in Metastatic Castration-Resistant Prostate Cancer

et al. 2020

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Rationale Radiolabelled bisphosphonates such as 99mTc-DPD typically show intense uptake in skeletal metastases from metastatic castration resistant prostate cancer (mCRPC). Extensive bone involvement is regarded a risk factor for mCRPC patients treated with 223Ra-radiumdichloride (223Ra). Aim of this study was to quantify 99mTc-DPD uptake by means of SPECT/CT prior to 223Ra and compare results to the feasibility of treatment and overall survival (OS). Methods 60 consecutive mCRPC patients were prospectively included into this study. SPECT/CTs of the central skeleton covering the scull to mid-femoral level were carried out before the first cycle of 223Ra. The bone compartment was defined by means of low-dose CT. Emission data were corrected for scatter, attenuation and decay supplemented by resolution recovery using dedicated software. The Kaplan-Meier estimator, U-Test and Cox regression analysis were employed for statistics. Results Total 99mTc-DPD uptake of the central skeleton varied between 11-56 percent of injected dose (%ID) or 1.8-10.5 %ID/1000 ml bone volume (%ID/L). SUVmean ranged from 1.9-7.4 while SUVmax range was 18-248. Patients unable to complete 223Ra treatment due to progression a/o. cytopenia (n=23) showed significantly higher uptake (31.9 vs. 25.4%ID; 6.0 vs 4.7x %ID/L, P <0.02). OS after 223Ra (median: 15.2 months) was reduced to 7.3 months in case of skeletal uptake ≥26 %ID as compared to 30.8 months if <26 %ID (p=0.008). Similar results were obtained for %ID/L and SUVmean. SUVmax was not correlated to survival. %ID/L was identified as an independent prognostic factor for OS (Hazard ratio 1.381 per unit) along with number of previous treatment lines. Conclusion Quantitative SPECT/CT of bone scans performed at baseline is prognostic for survival of mCRPC patients treated with 223Ra.

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“…The global FDD classification test Sensitivity was evaluated for the major faults. For the experiments, this is evaluated by dividing the number of correct channel statuses by the number of introduced faults: true positives positive conditions (1) The global FDD Specificity was evaluated as the number of correctly identified working channels divided by the number of properly working channels:…”

Section: B Global Diagnosis Statisticsmentioning

confidence: 99%

Automatic Channel Fault Detection and Diagnosis System for a Small Animal APD-Based <newline/>Digital PET Scanner

Charest

Cadorette

Brunet

et al. 2015

IEEE Trans. Nucl. Sci.

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Abstract-Fault detection and diagnosis is critical to many applications in order to ensure proper operation and performance over time. Positron emission tomography (PET) systems that require regular calibrations by qualified scanner operators are good candidates for such continuous improvements. Furthermore, for scanners employing one-to-one coupling of crystals to photodetectors to achieve enhanced spatial resolution and contrast, the calibration task is even more daunting because of the large number of independent channels involved. To cope with the additional complexity of the calibration and quality control procedures of these scanners, an intelligent system (IS) was designed to perform fault detection and diagnosis (FDD) of malfunctioning channels. The IS can be broken down into four hierarchical modules: parameter extraction, channel fault detection, fault prioritization and diagnosis. Of these modules, the first two have previously been reported and this paper focuses on fault prioritization and diagnosis. The purpose of the fault prioritization module is to help the operator to zero in on the faults that need immediate attention. The fault diagnosis module will then identify the causes of the malfunction and propose an explanation of the reasons that lead to the diagnosis. The FDD system was implemented on a LabPET TM avalanche photodiode (APD)-based digital PET scanner. Experiments demonstrated a FDD Sensitivity of 99.3 % (with a 95% confidence interval (CI) of [98.7, 99.9]) for major faults. Globally, the Balanced Accuracy of the diagnosis for varying fault severities is 92 %. This suggests the IS can greatly benefit the operators in their maintenance task.

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Five-year experience of quality control for a 3D LSO-based whole-body PET scanner: Results and considerations

Cited by 13 publications

References 11 publications

Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

The Prognostic Value of Quantitative Bone SPECT/CT Before ²²³Ra Treatment in Metastatic Castration-Resistant Prostate Cancer

Automatic Channel Fault Detection and Diagnosis System for a Small Animal APD-Based <newline/>Digital PET Scanner

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Five-year experience of quality control for a 3D LSO-based whole-body PET scanner: Results and considerations

Cited by 13 publications

References 11 publications

Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

The Prognostic Value of Quantitative Bone SPECT/CT Before 223Ra Treatment in Metastatic Castration-Resistant Prostate Cancer

Automatic Channel Fault Detection and Diagnosis System for a Small Animal APD-Based <newline/>Digital PET Scanner

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The Prognostic Value of Quantitative Bone SPECT/CT Before ²²³Ra Treatment in Metastatic Castration-Resistant Prostate Cancer