Characterization of the [153Sm]Sm-EDTMP pharmacokinetics and Estimation of radiation absorbed dose on an individual Basis

Therapeutic bone response of breast cancer recurrences on single sm-153 EDTMP treatment (+/- influence of statin intake)

“…Another study by Vigna et al calculated the activity dose delivered to the bone surface and red marrow in 20 patients treated with 153-Sm EDTMP, administering a fixed activity per kg (37 MBq/kg). Blood and urinary samples were collected for 24 h post treatment, reported a high bone and marrow activity dose among prostate cancer patients with osteoblastic bone lesions while, in breast cancer with osteolytic or mixed lesions showed no statistical diference in clinical results among them [22].…”

Estimated human absorbed dose of a new 153Sm bone seeking agent based on biodistribution data in mice: Comparison with 153Sm-EDTMP

“…Due to the high radio-sensitivity of hematopoietic cells within marrow of trabecular bone cavities, the bone marrow is a main critical organ for metastatic bone pain palliation therapy [20]. Nonetheless, the ratio of bone surface to red marrow, urinary bladder, muscle, gallbladder, small intestine and total body is greater for 153 Sm-BPAMD compared to 153 Sm-EDTMP.…”

Human absorbed dose estimation for a new 175Yb-phosphonate based on rats data: Comparison with similar bone pain palliation agents

“…This concern is naturally heightened in therapy applications where a significant absorbed dose may be received by other organs and in particular by radiosensitive organs (Stabin et al, 1996). Due to the high radio-sensitivity of hematopoietic cells within marrow of trabecular bone cavities, the most important challenges in developing new agents for bone pain palliation therapy is to deliver adequate dose of ionizing radiation to the skeletal lesion sites while the absorbed dose of the red marrow should be kept as low as possible (Vigna et al, 2011). Radionuclides with low beta particle energy are recommended for bone pain palliation as they have approximately insignificant effects on the bone marrow and therefore, those with higher energies are used for bone marrow ablation (Bouchet et al, 2000).…”