A sensitive and specific radioimmunoassay was developed for the precursor-specific peptide segment located at the amino end of bovine type III procollagen. Human material showed high cross-reactivity in this assay. Two forms of human procollagen peptides were detected in body fluids. The larger peptide (45K) was found in serum and ascites, and resembled the whole precursor-specific segment which is presumably released from human type III procollagen by a single enzymatic cleavage. The smaller peptide (10K) was found mainly in urine indicating that further degradation of circulating procollagen peptides is required prior to their passage through the kidney. Compared to peptide concentrations in normal human serum two to twenty-fold increases were observed in all patients with alcoholic liver disease, in fifteen of seventeen patients with acute hepatitis, and in ten of fourteen patients with chronic active hepatitis. Much higher levels were detected in ascites fluid. Patients with rheumatoid arthritis and other diseases showed far smaller elevations of the serum peptide. In alcoholic liver disease peptide levels correlated well with inflammation and necrosis observed in liver biopsies, but not with other laboratory parameters.

A 42−year−old woman was admitted to the emergency room because of bilious vomiting and intense epigastric pain. She was unable to tolerate liquids and had moderate signs of dehydration. She had eaten raw fish (sushi) the day before. The patient was hospitalized and rehydrated. She stopped vomiting but the epigastric pain was not controlled. She underwent upper gastrointestinal endoscopy which revealed numerous erosions and ulcers in the gastric body. A parasite with the appearance of an adult Anisakis was found adherent to and penetrating the central part of an ulcer. It was withdrawn with a polypectomy snare. There was a rapid relief of symptoms. The parasitolo− gy report identified Anisakis simplex (l " Fig. 1). Anisakiasis is related to the ingestion of raw or undercooked fish and occurs in Japanese culture (sushi, sashimi), areas in South America ("ceviche"), Spain ("vin− egar anchovies") and the Netherlands (raw fish) [1]. Anisakiasis can become a serious clinical problem when it causes gastric involve− ment, with ulcerations, pain and, rarely, intramural pseudotumors. Gastric in− volvement occurs in 90 % of cases. When upper gastrointestinal endoscopy is per− formed 1 or 2 days after infection, the en− doscopic findings are of redness and ero− sions or ulcerations at the site of penetra− tion of the gastrointestinal wall (l " Fig. 2) [2]. Steroid treatment often solves the crisis, but only expulsion of the worm or its endoscopic removal with a biopsy for− ceps calms the pain [3] (l " Fig. 3). The best solution to anisakiasis in humans is to prevent it by avoiding water contami− nation and by freezing fish that is to be eaten raw at ± 20 8C for at least 5 days or at ± 35 8C for 15 h.

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OBJETIVO: Determinar los riesgos asociados al síndrome metabólico en pacientes con psoriasis atendidos en el servicio de dermatología del Hospital “María Auxiliadora” Enero – Diciembre 2018. DISEÑO: Estudio de tipo analítico, caso-control, cuantitativo, retrospectivo y transversal. Se revisaron 225 historias clínicas de pacientes con psoriasis; los casos fueron 71 pacientes con síndrome metabólico y el grupo de control 142 pacientes sin síndrome metabólico. Se utilizó una ficha de recolección de datos acerca de los riesgos asociados a síndrome metabólico: factores sociodemográficos; factores clínicos; antecedentes personales y antecedentes patológicos. Las variables se analizaron en el programa estadístico SPSS versión 25. RESULTADOS: Existe asociación estadísticamente significativa entre: edad adulto (valor p=0.000; OR:2.985; IC95% 1.622- 5.496);el sexo femenino (valor p=0.003; OR:2.456; IC95% 1.357- 4.442); variante clínica vulgar (p=0.029; OR:.3.280; IC95% 1.304-8.251); gravedad de psoriasis moderada (p=0.000; OR 4.982; IC95% 2.700-9.193); sedentarismo (p=0.000; OR:3.855; C95% 2.099-7.080); alimentación no saludable(p=0.000; OR:3.835; IC95% 2.100- 7.004); consumo de alcohol(p=0.001; OR:2.76; IC95% 1.491-4.806); IMC de sobrepeso ( p=0.000; OR=1.434; IC95% 1.076-3.477) y obesidad (p=0.000; OR=1.076; IC95% 1.772-6.986);hígado graso(p=0.011; OR:2.099; IC95%1.177-3.744) y diabetes(p=0.009, OR:2.208; IC95%1.216-4.008) como riesgo asociados a síndrome metabólico en pacientes con psoriasis. CONCLUSIONES: La edad, el sexo, la variante clínica psoriásica, la gravedad de psoriasis, el sedentarismo, el tipo de alimentación, consumo de alcohol, el IMC, hígado graso y diabetes; son riesgos asociados al desarrollo de síndrome metabólico en pacientes con psoriasis, atendidos en el servicio de dermatología del Hospital “María Auxiliadora” enero-diciembre 2018.