The tissue engineering construction was developed from human bone marrow multipotent stromal cells and 3D porous foamed-ceramic carriers of a zirconium oxide-aluminum oxide system. The carriers had no cytotoxic activity and were potent in maintaining the cell adhesion and proliferation. We developed the method for inoculation and cultivation of bone marrow multipotent stromal cells on these carriers. The optimal time of incubation to obtain a tissue engineering construction was estimated. Bone marrow multipotent stromal cells could be cultured at a depth of 9 mm from the edge of the matrix. The tissue engineering construction holds promise for the repair of extensive defects in bone tissue.
Zirconia-alumina ceramic foam scaffolds with a nanocrystalline HAP coating were used for the preparation of integrated motile orbital implants. This study demonstrated that open-cell ceramic foams with enhanced strength-to-density ratio are quite suitable as biocompatible materials for the manufacture of orbital implants for post-enucleation syndrome treatment. In-vivo studies demonstrated that the application of a nanocrystallyne (not sintered) HAP coating facilitated the formation of dense fibrous capsule around the implant as well as the fast tissue ingrowth into the implant’s internal space. Orbital implants with the optimized pore size and HAP content were implanted to the animal’s eye cavity with their fixation to the extraocular muscles, and their motility was ensured.
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