Evaluation of resorbable polydioxanone and polyglycolic acid meshes in a rat model of ventral hernia repair

Abstract

The objective of this study was to evaluate physical, mechanical, and biological properties of the polydioxanone (PDO) monofilament meshes and polyglycolide (PGA) polyfilament meshes in comparison with Permacol implants. In rat experimental model, a 1.5 × 2.0 cm defect in abdominal wall was reconstructed by using the Permacol surgical implant or knitted meshes produced from either PDO monofilament, or PGA multifilament. The implant sites were assessed for the tensile strength and the extents of material resorption, host inflammatory response and host tissue replacement on days 3, 10, 30, or 60 after the surgery. The PDO and PGA meshes were rapidly pervaded by the host connective tissue with elements of skeletal muscle histogenesis. The degree of adhesions was significantly higher in the Permacol group. All of the prostheses underwent resorption, which correlated with gradual decreases in the overall tensile strength of the site and the Col1a1 gene expression level. Elevated expression of Fgf2 gene maintained longer in the PDO group, and the Mmp9 gene expression level in this group was higher than in the other groups. Gene expression levels of inflammatory cytokines were higher in the Permacol group. The foreign body giant cell numbers were lower in the PDO and Permacol groups than in the PGA group. Minimal macrophage infiltration with predominance of M2 cells was observed in the PDO group. Overall, the PDO prosthesis turned out to be significantly better than the PGA or Permacol prostheses by a number of indicators of biocompatibility and efficacy. © 2018 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 00B: 000-000, 2018.

Bioabsorbable Polydioxanone Mesh for Soft Tissue Reinforcement in Revisional Breast Surgery

“…The mesh is a monofilamentous construct and the constituent PDO offers intermediate in vivo durability of approximately 6 to 8 months in contrast to polyglactin 910 (2-4 months) and P4HB (18-24 months), combined with superior biocompatibility. 17 This is in line with preclinical data demonstrating evidence of mesh incorporation at 1 month and resolution of ongoing foreign body reaction by the 12-month mark. 18-20 The mid-range bioabsorption timeframe of PDO aims to strike the balance of providing mechanical support until the natural wound healing process is able to replace the mesh prosthesis with a stable capsule while avoiding long-term surgical site complications.…”

Polydioxanone-Based Membranes for Bone Regeneration

“…An ideal synthetic resorbable material must exhibit high porosity to promote tissue ingrowth and reduce the risk of tissue defect recurrence [ 42 ]. Therefore, the structural morphology and superficial topography of the PDO membrane examined in this study are similar to those of the ECM ( Figure 1 ), in which the physicochemical and morphological properties facilitate the diffusion of biological fluids and cell adhesion [ 4 ].…”

New Insights into the Application of 3D-Printing Technology in Hernia Repair

“…These devices are made of one or more degradable materials which biodeteriorate in the short-term (days-weeks), mid-term (weeks-months) or long-term (months-years). Resorbable meshes are mainly composed of poly-4-hydroxybutyrate (P4HB) [40], polyglactin (PGL) [41], polylactic acid (PLA) [42], polyglycolic acid (PGA) [43], trimethylene carbonate (TMC) [44], polycaprolactone (PCL) [45], polyvinyl alcohol (PVA) [46], and combinations of these.…”