No abstract

Neuronal degeneration due to oxidative stress (OS) has been proposed as a mechanism for tardive dyskinesia (TD) pathogenesis. Cellular defense mechanisms against OS may involve detoxification enzymes (e.g., glutathione peroxidase-1, GPX1; superoxide dismutase-2, SOD2 [also commonly known as MnSOD]; and glutathione S-transferase P1, GSTP1). Several pharmacogenetic studies have examined TD and OS in different ethnic groups, but not in Russians. Here we report the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and polymorphisms of GSTP1 (Ile105Val), MnSOD (Ala-9Val), and GPX1 (Pro197Leu) genes in 146 Russian inpatients from Siberia. We applied AIMS instrument to rate dyskinesias. Two-part model analyses, logistic and multivariate parametric regressions were applied to assess the effects of different variables (e.g., genotype, age, gender, and medication use). Our analyses do not suggest that Pro197Leu (GPX1) is associated with TD. However, our analyses suggest that the 105Val-allele of Ile105Val (GSTP1) may be associated with a lower risk and a severity of TDof and TDlt and that Ile105Val pharmacogenetics may be different in Slavonic Caucasians from that in American Caucasians. Furthermore, we find evidence for an association between Ala-9Val (MnSOD) and TDof, but not TDlt. Subject to further replication, our findings extend the available knowledge on the pharmacogenetics of TD and oxidative stress.

Objective:Study concentrations of steroid and thyreoid hormones in patients with neurotic, stress-related and somatoform disorders.Methods:35 patients with dissociative (conversion) disorders (ISD-10, F44), 29 patients with adjustment disorders (ISD-10, F43.2) and mentally healthy persons (27 persons) were investigated. Immunofermantal analysis for definition of concentration of steroid and thyreoid hormones were carried out.Results:We have observed statistically significant increased level of cortizol (p< 0,05) in patients with adjustment disorders (635,04±48,69 nmol/l) in comparison with control and patients with dissociative (conversion) disorders (444,97±24,53 nmol/l and 443,13±23,00 nmol/l accordingly). The statistically significant the lowered maintenance of dehydroepiandrosteronum is characteristic for patients with adjustment disorders in comparison with control and patients of another group (3,9±0,26; 6,35±0,62 and 6,69±0,50 mkmol/l accordingly, p< 0,05). For patients with dissociative (conversion) disorders is characteristic the statistically significant increased level of triiodthyronin (1,71±0,12 nmol/l), in patients with adjustment disorders and mentally healthy persons this metric composed 1,26±0,02 nmol/l and 1,34±0,04 nmol/l accordingly. The level of thyroxin for the persons with dissociative (conversion) disorders differ from values of control and patients with adjustment disorders (23,68±2,07 pkmol/l; 17,64±1,43 pkmol/l and 14,69±0,53 pkmol/l accordingly, p< 0,05).Conclusion:For patients with adjustment disorders is characteristic the statistically significant increased level of cortizol and the lowered maintenance of dehydroepiandrosteronum. Dissociative (conversion) disorders are formed in conditions of the raised maintenance thyreoid hormones and the physiological maintenance of steroid hormones.The investigation supported by project of RHSF №06-06-00691а, №07-06-95673и/М and №08-06-00284а.

Objective:Study biological markers of families with neurotic, stress-related and somatoform disorders for definition of probability of occurrence of mental disorders.Methods:131 families of patients with neurotic, stress-related and somatoform disorders. The clinical and genealogical analysis, immunofermantal analysis for definition of concentration of steroid and thyreoid hormones, estimate of processes of apoptosis at receptor and cell-like levels for patients and relatives of the first degree of relationship were carried out.Results:Spreading of mental pathology among relatives was about 6,85 %. There was the accumulation of repeated cases of similar disorders in these families and basic share of pathology was marked among the first degrees of relationships. Among relatives of patients the group of the raised risk of occurrence of mental disorders is revealed: 1,35 siblings; 1,04 children; 0,3 grandsons; 0,85 spouses corresponds to 1 patient. The statistically significant increased levels of cortizol, triiodthyronin and thyroxine (p<0,05) and the lowered maintenance of dehydroepiandrosteronum (p<0,05) is characteristic for patients in comparison with control. We have observed statistically significant increase of expression of a receptor CD95 in patients in comparison with control (p<0,05). For patients is characteristic the statistically significant increase of levels of spontaneous apoptosis of neutrophils (p<0,05) and lymphocytes. For their relatives is characteristic the tendency to an amplification of this process.Conclusions:Neurotic disorders are accompanied by features of biological processes, the knowledge of these features will allow rendering assistance with great efficiency.The investigation supported by project of RHSF №06-06-00691а.

Исследовано содержание стероидных и тиреоидных гормонов и полиморфизм генов 5-HTR2A и 5-HTT у , лиц с истерическими расстройствами невротического уровня расстройствами адаптации с преобладанием депрессивных реакций и . . у психически здоровых лиц Выявлены гормональные особенности и генетические полиморфизмы Ключевые слова: , . стероидные и тиреоидные гормоны гены серотонинового обменаThe concentrations of steroid and thyreoid hormones and polymorphic variants of genes 5-HTR2A and 5-HTT at patients with dissociative (conversion) disorders, patients with adjustment disorders and mentally healthy persons has beeng studied. We revealed the hormonal peculiarities and genetic polymorphisms.