Hormonal parameters and genetic polymorphism at norm and neurotic stress-related disorders

Ryadovaya, L.; Gutkevich, Ye. V.; Ivanova, Svetlana A.; Semke, V.; Yepanchintseva, Ye. M.

doi:10.20538/1682-0363-2008-3-19-23

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Именно поэтому изучение потребности в психиатрической и психолого-психотерапевтической помощи и оценка заболеваемости крайне затруднены, что заставляет исследователя заниматься поиском решений в получении достоверной информации и проведении адекватной оценки заболеваемости и потребности в психиатрической и психолого-психотерапевтической помощи. Именно поэтому в исследовании представлен современный формат сбора материала и оценки реальной потребности в психолого-психотерапевтической и психиатрической помощи для формирования системы маршрутизации населения, направленной на предоставление адекватной адресной психолого-психотерапевтической и психиатрической помощи [1][2][3][4][5][6][7][8][9][10].…”

Section: оригинальные исследованияunclassified

Socio-medical profile of the population in matters of organization of psychological, psychotherapeutic and psychiatric care

Shapovalova,

Levin,

Boyko

et al. 2023

Russian Military Medical Academy Reports

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BACKGROUND: This study is due to the need to study the psychological safety of a person, since various social upheavals, the COVID-10 pandemic, military conflicts are stress factors in the formation of not only somatic morbidity, but also mental disorders in the population. For this reason, the study contains a comprehensive empirical collection of material and an assessment of the real need for psychological, psychotherapeutic and psychiatric care in order to compile a population routing system aimed at providing adequate targeted psychological, psychotherapeutic and psychiatric care. AIM: Assess the socio-medical profile of the population for an adequate organization of psychological, psychotherapeutic and psychiatric care. MATERIALS AND METHODS: In shaping the need for psychological, psychotherapeutic and psychiatric care, women of working age, with a working status, mostly married, who had a mild to moderate Covid-19 disease, who felt unwell, lack of strength, increased fatigue, showing a desire to turn to both a psychologist and a psychotherapist and a psychiatrist. RESULTS: The socio-medical determinants of the need for psychological, psychotherapeutic and psychiatric care included signs between which a close correlation was revealed: Memory decline, difficulties in mastering a new one and Reduced performance; difficulties in communicating with others (R = 0.7), Reduced performance; difficulties in communicating with others and Willingness to see a psychotherapist (R = 0.64), Depressive mood and Decreased memory, difficulty communicating with people (R = 0.76), Depressive moodand Decreased performance (R = 0.76), Depressive mood and Willingness to seek counseling from a psychiatrist (R = 0.51), Age and Chronic diseases (R = 0.55). CONCLUSION: The results obtained serve as the basis for the formation of a population routing system to provide adequate targeted psychological, psychotherapeutic and psychiatric care.

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Section: оригинальные исследованияunclassified

Socio-medical profile of the population in matters of organization of psychological, psychotherapeutic and psychiatric care

Shapovalova,

Levin,

Boyko

et al. 2023

Russian Military Medical Academy Reports

View full text Add to dashboard Cite

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Biomarkers of stress in children with asthenic syndrome associated with aluminum contamination in biological media and A/G polymorphism of the HTR2A (rs7997012) serotonin receptor gene

Dolgikh,

Zaitseva,

Subbotina

et al. 2023

Hygiene and Sanitation

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Introduction. Ambient air pollution with heavy metals, included aluminum, creates their elevated levels in children and leads to rather early decompensation of weak genetically heritable systems of the body including the nervous system. Materials and methods. We examined eighty six 4–7 years children with asthenic syndrome. Fifty two of them (the test group) lived and attended preschool facilities in a zone influenced by emissions from aluminum production (a dose created by a non-ferrous metallurgic plant is 5.65•10–5 mg/(kg•day)). The reference group was made of 34 children who lived on a conditionally clean territory and were exposed to airborne aluminum in a dose of 3.0•10–6 mg/(kg•day). Within this study, there were examined several children’s biological media including urine (aluminum), blood (serotonin and cortisol), and buccal epithelium (HTR2A rs7997012 gene). Differences were considered to be significant at a p<0.05. Results. We established statistically significantly higher aluminum levels in urine (1.3 times higher) in the test group against the reference one (0.012±0.0001 and 0.0092±0.0012 respectively); authentically higher prevalence of the minor allele G of the HTR2A (rs7997012) serotonin receptor gene (authentically 1.6 times higher in the test group against the reference one). Both these factors create an elevated risk of asthenic syndrome, 1.86 times higher in the test group (OR=1.86; 95%CI (1.02–3.67)) together with lower serotonin levels (130.28±32.42 ng/ml and 183.35±34.57 ng/ml respectively) and higher cortisol levels (278.08±25.90 nmol/cm3 and 191.28±21.62 nmol/cm3 respectively). Limitations. The limitation is application of the identified stress biomarkers for diagnostics of nervous system disorders that manifest themselves in children through asthenic syndrome associated with exposure to aluminum. Conclusion. A/G replacement of the HTR2A (rs7997012) gene creates a 1.86 times higher risk of asthenic syndrome (OR=1.86; 95%CI (1.02–3.67)) for children with elevated aluminum levels in urine under inhalation exposure to it in a dose equal to 5.65•10–5 mg/kg•day). The disease would have such a peculiarity as longer recurrence and its biomarkers include an imbalance between indicators of a developing stress, cortisol, and serotonin.

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Hormonal parameters and genetic polymorphism at norm and neurotic stress-related disorders

Cited by 2 publications

References 6 publications

Socio-medical profile of the population in matters of organization of psychological, psychotherapeutic and psychiatric care

Socio-medical profile of the population in matters of organization of psychological, psychotherapeutic and psychiatric care

Biomarkers of stress in children with asthenic syndrome associated with aluminum contamination in biological media and A/G polymorphism of the HTR2A (rs7997012) serotonin receptor gene

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