Summary. The dilutions of labelled red blood cells and labelled albumin were studied over a 10 hour period in HbA and HbB sheep, both before and after splenectomy.The dilution curves were analysed into exponentials, and values for red blood cell volume and plasma volume were calculated from various portions of the curves.Dilution curves for labelled red blood cells in intact sheep showed important differences from those in splenectomized sheep.Red blood cell volume was calculated from: The extrapolation of the exponential process with the slowest decay rate; the sum of intercepts of all exponential processes; jugular haematocrit and plasma volume. Splenectomy significantly reduced the values for these parameters.Plasma volume was calculated from the extrapolation of the exponential with the slowest decay rate and from the sum of intercepts of all exponential processes. Splenectomy significantly reduced the values for these parameters.Blood volume and the value for the ratio of body to jugular haematocrit were calculated from the data, and were found to be significantly reduced by splenectomy.Diiferences between HbA and HbB sheep were found only for jugular haematocrit and red blood cell volume calculated from jugular haematocrit and plasma volume.The differences in values from the several methods of calculating red blood cell volume in intact sheep and the reduction of these values by splenectomy are discussed in relation to the splenic red blood cell content.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.