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2005Multi-membered N-heterocycles R 0690Synthesis of Substituted 5,6-Dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepines. -The thermal cyclization of (I) is a one-pot approach to the title compounds (II). The in vitro anticancer activity of some compounds is tested. Interesting effects are only observed for derivative (IIb). -(KOSYCHOVA, L.; STUMBREVICIUTE, Z.; PLECKAITIENE, L.; JANCIENE, R.; PUODZIUNAITE, B. D.; Chem.

The synthesis of 2-substituted imidazo[1,2-a] [1,5]benzodiazepines is accomplished from tetrahydro-1,5-benzodiazepin-2-ones and α-haloketones. The structure and stereochemistry of the ring system obtained were investigated by 1 H and 13 C NMR spectroscopy.

Multi-membered N-heterocycles R 0690Tautomerism of the Thioamide Group in 4-Methyl-7-nitro-2,3,4,5-tetrahydro-1,5-benzodiazepine-2-thione. -Treatment of 7-nitrobenzodiazepin-2-one (I) with P 2 S 5 provides the expected thione (II) and its stable thiol tautomer (III), which can be smoothly converted to crystalline acetylhydrazino derivative (VII) via the S-methyl derivative (V). -(JANCIENE, R.; STUMBREVICIUTE, Z.; PLECKAITIENE, L.; PUODZIUNAITE, B.; Chem. Heterocycl. Compd. (N. Y.) 38 (2002) 6, 738-740; Inst. Biochem., Vilnius 2600, Lithuania; Eng.) -M. Schroeter 09-161