Tautomerism of the Thioamide Group in 4‐Methyl‐7‐nitro‐2,3,4,5‐tetrahydro‐1,5‐benzodiazepine‐2‐thione.

Abstract

Multi-membered N-heterocycles R 0690Tautomerism of the Thioamide Group in 4-Methyl-7-nitro-2,3,4,5-tetrahydro-1,5-benzodiazepine-2-thione. -Treatment of 7-nitrobenzodiazepin-2-one (I) with P 2 S 5 provides the expected thione (II) and its stable thiol tautomer (III), which can be smoothly converted to crystalline acetylhydrazino derivative (VII) via the S-methyl derivative (V). -(JANCIENE, R.; STUMBREVICIUTE, Z.; PLECKAITIENE, L.; PUODZIUNAITE, B.; Chem. Heterocycl. Compd. (N. Y.) 38 (2002) 6, 738-740; Inst. Biochem., Vilnius 2600, Lithuania; Eng.) -M. Schroeter 09-161