Under the conditions of this study, oral salbutamol appears to be an effective ergogenic aid in nonasthmatic individuals not experiencing adverse side effects.

The metabolism of the human forearm was studied in healthy volunteers by the registration of arterial and deep-venous concentrations of oxygen and glucose and of resting forearm blood flow during the intrabrachial arterial infusion of 0.9% NaCl (n = 4), papaverine (n = 5), bradykinin (n = 9) and bradykinin after the oral pretreatment with indomethacin, an inhibitor of prostaglandin synthesis (n = 10). The blood flow was not affected during the infusion of NaCl (0.2 m//min) but was increased, depending on the concentrations, 2-and 3-fold during infusion of papaverine (2 or 3 /ig/(kg χ min)), and 2-fold during infusion of bradykinin (0.2 ng/(kg χ min)).The latter effect on the blood flow was significantly smaller when endogenous synthesis of prostaglandins was impaired by indomethacin pretreatment. Arterial oxygen and glucose concentrations were maintained during the individual infusions. This was also true for the arterial-deepvenous concentration differences of oxygen and glucose during NaCl infusions. Corresponding to the acceleration of the blood flow caused by papaverine and bradykinin, arterial-deep-venous concentration oxygen differences declined, indicating that oxygen consumption of the muscle was not changed. A similar behaviour was observed for muscukr extraction and consequently uptake of glucose when the acceleration of the blood flow was caused by papaverine. In contrast, doubling of the blood flow caused by the infusion of bradykinin was accompanied with enlargement of the arterial-deep-venous concentration difference and thus of muscular glucose uptake. There was no change in the arterial and forearm deepvenous levels of insulin under these conditions. Also, this effect of bradykinin was nearly abolished after oral pretreatment with indomethacin. From these data one may suggest that bradykinin, besides its well-known action on blood flow, also affects the glucose metabolism of the human forearm apparently via endogenously synthetized prostaglandins. Bradykinin und Unterarmstoff wechsel: Hemmung der endogenen ProstaglandinSyntheseZusammenfassung: An gesunden Probanden wurde der Stoffwechsel des Unterarms studiert. Dazu wurden die arteriellen und tiefvenösen Konzentrationen von Sauerstoff und Glucose sowie der Unterarmdurchfluß gemessen. Dies geschah während einer Infusion von 0.9% NaCl (η = 4), von Papaverin (η = 5), von Bradykinin (n = 9) sowie von Bradykinin nach oraler Vorbehandlung mit Indomethacin, einem Inhibitor der Prostaglandin-Biosynthese (η = 10). Infusion von NaCl änderte den Unterarmdurchfluß nicht, während Papaverin (2 und 3 μ% χ kg -1 χ min -1 ) ihn kon-

No abstract

No abstract