Effect of salbutamol on muscle strength and endurance performance in nonasthmatic men

Abstract

Under the conditions of this study, oral salbutamol appears to be an effective ergogenic aid in nonasthmatic individuals not experiencing adverse side effects.

Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise

“…Potassium clearance during exercise also occurs via uptake by other non-contracting or relatively inactive muscles, and also splanchnic K + uptake (Lindinger 1995;Sejersted and Sjøgaard 2000;Clausen 2003 (Hostrup et al 2014a;Collomp et al 2000;Grove et al 1995;Newnham et al 1993;Van Baak et al 2000), or in samples drawn only after completion of, rather than during exercise (Hostrup et al 2014a;Kalsen et al 2014;Hostrup et al 2014b;Larsson et al 1997;Grove et al 1995); and/or utilised oral salbutamol (Collomp et al 2000;Van Baak et al 2000;Hostrup et al 2014a;Goubault et al 2001 after prolonged cycling to exhaustion (Van Baak et al 2000), or at 5-10 min recovery after repeated 30 s sprints or repeated bouts of high intensity cycling, although greater reductions were evident at 1 or 2 min after some individual bouts (Hostrup et al 2014a). Similarly, after salbutamol inhalation (800 µg), there was no further change in antecubital venous [K + ] at 2-10 min after exhaustive cycling at 85% VO 2peak (Goubault et al 2001).…”

“…Salbutamol typically does not enhance performance during endurance exercise (Koch et al 2015;Pluim et al 2011), when K + disturbances are modest (Sejersted and Sjøgaard 2000), with some exceptions, where venous [K + ] was also reduced by ~0.2-0.4 mM (Van Baak et al 2000;Collomp et al 2000). Performance during a 30 s cycle sprint was enhanced by oral salbutamol (4-8 mg) (Le Panse et al 2007;Collomp et al 2005;Hostrup et al 2014a), with the post-exercise antecubital (Hostrup et al 2014a (Kalsen et al 2014).…”

“…However, salbutamol effects on [K + ] during intense exercise remain unclear, due to previous methodological limitations. Firstly, interpretation is difficult from studies measuring only antecubital venous [K + ] (Hostrup et al 2014a;Collomp et al 2000;Grove et al 1995;Newnham et al 1993;Van Baak et al 2000), as this can underestimate arterial [K + ] by as much as 2 mM during intense exercise, due to substantial K + clearance by forearm muscles (Lindinger 1995;McKenna et al 1997;Lindinger et al 1995;Kowalchuk et al 1988). Secondly, numerous studies measured [K + ] in blood drawn only after completion of exercise (Hostrup et al 2014a;Kalsen et al 2014;Larsson et al 1997;Grove et al 1995;Hostrup et al 2014b), when plasma [K + ] is falling precipitously (McKenna et al 1997;Sejersted and Sjøgaard 2000).…”

Pharmacokinetic parameters and a theoretical study about metabolism of BR-AEA (a salbutamol derivative) in rabbit

“…asthma, chronic obstructive pulmonary disease) in which salbutamol is the first-choice drug for stimulating  2 AR. 2 However, salbutamol has some disadvantages due to its side effects, [3][4][5] such as tachycardia and tremor, which are caused by the fact that salbutamol crosses the lipid barrier at alveolar-capillary units after pulmonary drug administration. 6 Another disadvantage is that this  2 AR agonist has a short half-life, 7 due to its fast metabolism in the intestine, liver, and lung (in order of capacity for the metabolism of salbutamol).…”

Kardiovaskuläre Nebenwirkungen von anabol-androgenen Steroiden

“…Für einige β 2 -Agonisten wie Clenbuterol und Salbutamol wurden aber darüber hinaus anabole Effekte nachgewiesen [17,70,108]. Der folgende Beitrag beschränkt sich auf Testosteron und dessen Derivate, also die Gruppe der AAS.…”