Two new antimetabolites of biotin were isolated from culture filtrates of
Streptomyces lydicus
: β-methyldethiobiotin and β-methylbiotin.
14
C-biotin or
14
C-pimelic acid was not incorporated into either of these antimetabolites by the growing culture. Neither of the compounds could substitute for the biotin requirement in
Saccharomyces cerevisiae
. Both compounds had a strong and rather specific antimicrobial effect against mycobacteria. Their antimicrobial activities were reversed by biotin. Both compounds had an affinity for avidin.
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