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We used the guinea pig as an experimental model to investigate the pathogenicity of Mycobacterium tuberculosis. Sputum samples were injected subcutaneously into guinea pigs and the animals were killed and an autopsy performed after eight weeks. The likelihood of the sputum samples producing tuberculosis in the guinea pig was related to culture positivity rather than to duration of chemotherapy. This study does not support the belief that a change in pathogenicity occurs during treatment of pulmonary tuberculosis.

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Conclusions 1) Delay within-patient was significantly longer than withinoncology (p<0.0001). 2) Over 60% patients visited their GP more than once. 3) Delay and stage were unrelated in our study. 4) Chest symptoms increased considerably during the pathway to treatment. 5) A number of common symptoms were associated with advanced disease.

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