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In previous studies, plasma glutamate concentration was lower when equivalent doses of monosodium L-glutamate (MSG) were given with a ready-to-feed liquid formula meal (Sustagen; 0.4 g protein, 1.1 g carbohydrate, 0.06 g fat, 6.6 kcal energy/kg body weight) rather than in water. This difference was suggested to reflect a carbohydrate effect on mucosal cell glutamate metabolism. To test this hypothesis, a large dose of monosodium L-glutamate (150 mg/kg body weight) dissolved in water, with or without added carbohydrate, was administered to eight healthy adult subjects. Carbohydrate was administered at 1.1 g/kg body weight in the form of partially hydrolyzed corn starch (Polycose). In the absence of carbohydrate, the mean (+/- SD) peak plasma glutamate concentration was 59.4 +/- 46.5 mumol/dl, and the incremental area under the plasma glutamate concentration time curve was 3391 +/- 2360 mumol/(dl x min). The addition of carbohydrate to the glutamate solution significantly decreased (p = 0.001) both the mean peak plasma glutamate concentration (7.18 +/- 3.48 mumol/dl) and the incremental area under the plasma glutamate concentration-time-curve (451 +/- 20.8 mumol/(dl x min). Erythrocyte glutamate and aspartate concentrations were not affected by glutamate loading in either test. Delayed gastric emptying did not account for the carbohydrate effect. Carbohydrate is postulated to serve as a pyruvate source for mucosal cells, facilitating the transamination of glutamate and its subsequent metabolism. This process would reduce the release of glutamate to the peripheral circulation.

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Analyses of sjw-Monooleyl-disaturated Triglycerides 167 angular distribution of intensity of scattered light is described.4. Measurements of turbidity, dissymmetry, refractive index increment and depolarization were made on solutions of four cellulose acetate fractions whose molecular weight had been otherwise determined. The molecular weights calculated from the optical measurements agreed within 8% of those measured by other means.5. The empirical constant, µ, which characterizes the deviation from van't Hoff law behavior was found to be 0.45 ± 0.01 by light scattering measurements as compared with 0.43 =±= 0.005 based on osmotic pressure measurements for the cellulose acetate-acetone system.6. The angular variation of intensity is found to be in agreement with the theoretical prediction.7. The comparison of the measured dissymmetry with that predicted theoretically for a rodshaped or random coil molecule indicates that the cellulose acetate molecule in acetone solution is rather extended up to a molecular weight of about 80,000. At higher molecular weights the molecule may coil back on itself to a degree that increases rapidly with molecular weight. Brooklyn, N. Y.