A new species of Brugia, from the lymphatic glands of dogs in Ceylon, is described. It is closely related to B. patei (Buckley, Nelson and Heisch, 1958).Also from dogs in Ceylon, a species of Dipetalonema was recovered whose relationship with other species of Dipetalonema is discussed. In the absence of conclusive evidence that it is a distinct species it is for the present regarded as a species inquirenda.
showed that members of a series of new quaternary ammonium compounds were active against a broad range of parasitic nematodes in laboratory and domestic animals. One of the most active compounds, bephenium embonate (benzyldimethyl-2-phenoxyethylammonium embonate), was shown by Rawes and Scarnell (1958) to be of value in the treatment of nematodiriasis in lambs. O)O.(CH1)2.N(CH3)2.CH2 0 mbonate The demonstration of high activity of bephenium salts against Ancylostoma caninum in dogs and cats (Copp et al., 1958) led naturally to preliminary trials in London against hookworm infections in man. We are indebted to Professor A. W. Woodruff, of the Tropical Diseases Hospital, and Drs. D. H. Garrett and M. J. Andrewes, of the Dreadnought Hospital, for carrying out these trials. The results were encouraging and justified more extensive trials against heavier hookworm infections in Ceylon. Tests in laboratory animals, including monkeys, showed that the toxicity of salts of bephenium was low. The less soluble salts, such as the 2-hydroxy-3naphthoate and embonate, were poorly absorbed when given by mouth to human volunteers (Rogers, 1958). Materials and Methods Experiments with A. caninum in dogs and cats (Burrows, 1958), Nippostrongylus muris in rats, and Nematospiroides dubius in mice (Copp and Standen, 1958, in preparation)
The results of the fluorescent antibody test with sera from tropical eosinophilia and filariasis cases tested against four species of microfilariae are reported. The majority of sera from both groups showed the presence of antibody to the human parasite W. bancrofti. In the filarial group only those with clinically active disease of short duration showed a positive fluorescence reaction. Some sera of both groups reacted positively with microfilariae of the animal parasites B. ceylonensis and Setaria sp. These were species specific reactions as seen by diminished or absence of fluorescence after absorption of specific antibody.
Two species of nematodes were recovered from the Meller's chamaeleon from Nyasaland, which died at the London Zoo. They comprised ten females and eight males of Foleyella candezi from the axilla and peritoneal cavity, and two adult females of Abbreviata sp. from the gut. Specific determination was not possible for the latter species, owing to the paucity of the material.The females are thread-like and very slightly flattened dorso-ventrally. They have an average length of 94.8 mm. and range from 73 to 124 mm. The width is more or less uniform, average 0.5 mm. but becomes narrow at 1 mm. from the tip of the tail. The anterior end is bluntly rounded and in some specimens has a slightly bulbous appearance when observed from the lateral aspect. This is due to a slight narrowing at the junction of the oesophagus and intestine.The tail is more attenuated than the anterior end and it is slightly curved ventrad and marked by a shallow groove running ventrally from the anus to the tip where it is flanked by two minute papillae-like structures.The shallow stoma is somewhat oval in shape and surrounded by ten minute papillae, six of which form an inner circle and four an outer circle. The mid-dorsal and mid-ventral papillae of the inner circle are more conspicuous than the others.
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